Drug information of Yohimbine

Mechanism of effect

Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated.

Pharmacodynamic

Yohimbine blocks presynaptic alpha-2 adrenergic receptors.

Pharmacokinetics

Rapidly absorbed following oral administration. Bioavailability is highly variable, ranging from 7 to 87% (mean 33%).Yohimbine appears to undergo extensive metabolism in an organ of high flow such as the liver or kidney, however, the precise metabolic fate of yohimbine has not been fully determined. Elimination half-life is approximately 36 minutes.

Drug indications

Erectile Dysfunction

Dosage

Usual Adult Dose for Erectile Dysfunction 5.4 mg orally 3 times a day. If side effects occur, reduce to 2.7 mg orally 3 times a day and titrate gradually up to 5.4 mg orally 3 times a day.

Drug contraindications

Pregnancy , Renal dysfunction , Lactation , hypersensitivity to drug or its components.

Side effects

Headache , dizziness , flushing , anxiety , Tremor

Interactions

Ergotamine-C , Liver health , Atenolol , Amlodipine , Amitriptyline , Spironolactone , Oxazepam , Enalapril , Clobazam , Clonazepam , Hydralazine , Hydrochlorothiazide , Valsartan , Verapamil , Captopril , Carvedilol , Methyldopa , Midazolam , Nortriptyline , Nitrazepam , Nifedipine , Nimodipine , Lorazepam , Losartan , Lisinopril , Minoxidil , Metoprolol , Metolazone , Diltiazem , Sotalol , Flurazepam , Phenoxybenzamine , Furosemide , Labetalol , Imipramine , Propranolol , Trimipramine , Desipramine , Doxepin , Diazepam , Phentolamine Mesylate , Bisoprolol , Nitroprusside sodium , rasagiline , Diethylpropion , Fosinopril , Ramipril , Doxapram , Telmisartan , Xylometazoline , Propylhexedrine , acrivastine+pseudoephedrine , Alfuzosin , Benzphetamine , Clorazepate , Quazepam , Guanadrel , iobenguane I 131

Alerts

1-Yohimbine is contraindicated for use in patients with renal disease. 2-The manufacturer recommends against the use of yohimbine in geriatric patients, patients with a psychiatric diagnosis, or cardiorenal patients with a history of gastric or duodenal ulcer. 3-Safety and effectiveness have not been established in pediatric patients (less than 18 years of age)

Points of recommendation

1-Use caution when driving, operating machinery, or performing other hazardous activities. Yohimbine may cause dizziness. If you experience dizziness, avoid these activities 2-Use caution when rising from a sitting or lying position. Yohimbine may be more likely to cause dizziness when changing positions.

Pregnancy level

Forbidden