Drug information of Solifenacin


Drug group:

Solifenacin reduces muscle spasms of the bladder and urinary tract. Solifenacin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, and incontinence (urine leakage).

Mechanism of effect

Inhibits muscarinic receptors resulting in decreased urinary bladder contraction, increased residual urine volume, and decreased detrusor muscle pressure.


Solifenacin is a competitive muscarinic receptor antagonist.


Metabolism:Extensively hepatic; Excretion:Urine (69%; <15% as unchanged drug); feces (23%) Time to Peak:Plasma: 3-8 hours Half-Life Elimination:45-68 hours following chronic dosing Protein Binding:~98% bound primarily to alpha1-acid glycoprotein


Dosing: Adult Overactive bladder: Oral: 5 mg once daily; if tolerated, may increase to 10 mg once daily Dosage adjustment with concomitant CYP3A4 inhibitors: Maximum solifenacin dose: 5 mg/day


1-patients must be cautioned about performing tasks which require mental alertness (eg, operating machinery or driving).
2-use caution in hot weather and/or exercise.
3-Cases of angioedema involving the face, lips, tongue, and/or larynx have been reported during treatment; some cases have occurred after the first dose. May be life-threatening. Immediately discontinue and institute supportive care if tongue, hypopharynx, or larynx is involved.

Points of recommendation

Swallow tablet whole; administer with liquids; may be administered without regard to meals.

Pregnancy level


Ask a Pharmacist

User's questions
    No comments yet.