Drug information of Albumin human

Albumin human

Drug group: Blood

Albumin (human) is a concentrate of plasma proteins from human blood. It works by increasing plasma volume or serum albumin levels.

Mechanism of effect

Acts as a high molecular weight, very soluble osmolyte

Pharmacodynamic

Regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.

Dosage

Usual Pediatric Dose for Hypoproteinemia Albumin 5%: Initial dose: 10 to 15 mL per pound (4.5 to 6.8 mL per kg) of body weight IV is usually adequate accompanied by close surveillance of the child. Usual Adult Dose for Hypoproteinemia Albumin 5%: Initial dose: 250 or 500 mL IV at a rate of 1 to 2 mL per minute in the absence of overt shock. The capacity of the administration set is the only limit in the exsanguinated patient. The rate of infusion and total volume administered are determined by the condition and response of the patient. The initial dose may be followed by additional albumin within 15 to 30 minutes if the response is inadequate. Albumin 25%: Initial dose: The patient may require 200 to 300 mL IV to reduce edema and to bring serum protein values to normal. Since such patients usually have approximately normal blood volume, doses of more than 100 mL of albumin 25% should not be given faster than 100 mL IV over 30 to 45 minutes to avoid circulatory overload. If slower administration is desired, 200 mL of albumin 25% may be mixed with 300 mL of 10% dextrose solution and administered by continuous drip at a rate of 100 mL an hour IV.

Interactions

intralipid

Alerts

1-Hypersensitivity or allergic reactions have been observed, and may in some cases progress to severe anaphylaxis. Epinephrine should be available immediately to treat any acute hypersensitivity reaction. 2-Hypervolemia may occur if the dosage and rate of infusion are not adjusted to the patient’s volume status. At the first clinical signs of possible cardiovascular overload, e.g., headache, dyspnea, increased blood pressure, jugular venous distention, elevated central venous pressure, pulmonary edema, the infusion should be stopped immediately and the patient reevaluated. 3-If comparatively large volumes are to be replaced, monitoring of coagulation and hematocrit is necessary 4-If Albumin (Human) 20% is to be administered, monitor hemodynamic performance regularly. this may include:: Arterial blood pressure and pulse rate, Central venous pressure, Pulmonary artery occlusion pressure, Urine output, Electrolytes, Hematocrit/hemoglobin.

Points of recommendation

This product is usually given in a hospital setting.

Pregnancy level

C


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