Drug information of Bella donna PB
Mechanism of effect
Belladonna is a term applied to the various galenical preparations of the naturally occurring solanaceous alkaloids.a Antimuscarinic activity results principally from the atropine (dl-hyoscyamine) content.a g
Competitively inhibits acetylcholine or other cholinergic stimuli at autonomic effectors innervated by postganglionic cholinergic nerves and, to a lesser extent, on smooth muscles that lack cholinergic innervation.c At usual doses, principally antagonizes cholinergic stimuli at muscarinic receptors and has little or no effect on cholinergic stimuli at nicotinic receptors.c
Tablets: 1-2 oral tablets three to four times a day
Slow-release tablets: 1 oral tablet twice a day / In case of patient care, up to three times a day, one tablet at a time is possible.
Elixir: 5-10 ml orally three times a day.
Hypersensitivity to belladonna, opium, or any component of the formulation; significant respiratory depression; acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment; use of monoamine oxidase inhibitors (concurrent or within 14 days); GI obstruction (known or suspected), including paralytic ileus; glaucoma; severe renal or hepatic disease; opioid idiosyncrasies; convulsive disorders; acute alcoholism; delirium tremens; premature labor.
Drowsiness, xerostomia, tachycardia, palpitation, dizziness, nervousness, urinary hesitancy and retention, decreased sweating, constipation, increased ocular tension, photophobia, blurred vision, mydriasis.
Before taking this medicine
You should not use Belladonna Tincture if you are allergic to it, or if you have:
a bladder obstruction, enlarged prostate, or other urination problems;
a stomach or bowel obstruction (including paralytic ileus);
severe ulcerative colitis or toxic megacolon;
chronic constipation or lack of bowel function (especially in older adults and those who are ill or debilitated);
heart problems, especially when caused by a thyroid disorder; or
active bleeding w