Drug information of Bupropion

Bupropion


Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.

Mechanism of effect

While the mechanism of action of bupropion, as with other antidepressants, is unknown, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms.

Pharmacodynamic

Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine and dopamine, and does not inhibit monoamine oxidase or the re-uptake of serotonin

Pharmacokinetics

Exposure to bupropion may be increased when bupropion hydrochloride extended-release tablets (SR) are taken with food. For sustained release, peak plasma concentrations are achieved within 3 hours. Bupropion is extensively metabolized in humans. Three metabolites have been shown to be active: hydroxybupropion. Following oral administration of 200 mg of 14C-bupropion in humans, 87% and 10% of the radioactive dose were recovered in the urine and feces, respectively.

Drug indications

Depression , Smoking Cessation

Dosage

Usual Adult Dose for Depression: Sustained-release tablets Initial dose:
150 mg orally once a day in the morning, increase if necessary after 3 days to 150 mg orally twice a day.
Maintenance dose: 150 mg orally twice a day Maximum dose: 200 mg orally twice a day; maximum single dose should not exceed 200 mg

Alerts

1-Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior
2- bupropion hydrochloride extended-release tablets (SR) are not approved for use in treating bipolar depression.
3-Patients should be made aware that bupropion hydrochloride extended-release tablets (SR) contain the same active ingredient found in ZYBAN®. bupropion hydrochloride extended-release tablets (SR) should not be used in combination with ZYBAN®, or any other medications that contain bupropion.
4-Bupropion hydrochloride extended-release tablets (SR) should be discontinued and not restarted in patients who experience a seizure while on treatment.
5-Bupropion hydrochloride extended-release tablets (SR) should be used with extreme caution in patients with severe hepatic cirrhosis.
6-Bupropion hydrochloride extended-release tablets (SR) should be used with caution in patients with renal impairment.
7-Antidepressants can precipitate manic episodes in bipolar disorder patients. Bupropion hydrochloride extended-release tablets (SR) are expected to pose similar risks.

Points of recommendation

1-Anaphylactoid/anaphylactic reactions characterized by symptoms such as pruritus, urticaria, angioedema, and dyspnea requiring medical treatment have been reported in clinical trials with bupropion. 2- bupropion hydrochloride extended-release tablets (SR) are not a treatment for quitting smoking, it contains the same active ingredient (bupropion hydrochloride) as ZYBAN® which is used to help patients quit smoking. 3-Take bupropion hydrochloride extended-release tablets (SR) exactly as prescribed by your doctor.

Pregnancy level

C

Related drugs

Vilazodone , Nicotine


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