Drug information of Papaverine

Papaverine

Drug group:

Papaverine is a vasodilator that relaxes smooth muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Papaverine is used to treat many conditions that cause spasm of smooth muscle. This includes chest pain, circulation problems, heart attack, or disorders of the stomach or gallbladder. Papaverine is not for use in treating erectile dysfunction (impotence) and should not be injected into the penis. This practice has resulted in painful or prolonged erection that may require surgery to correct.

Mechanism of effect

Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy.

Pharmacodynamic

The most characteristic effect of papaverine is relaxation of the tonus of all smooth muscle, especially when it has been spasmodically contracted. Papaverine Hydrochloride apparently acts directly on the muscle itself. This relaxation is noted in the vascular system and bronchial musculature and in thegastrointestinal, biliary and urinary tracts.

Pharmacokinetics

Papaverine is effective by all routes of administration. A considerable fraction of the drug localizes in fat deposits and in the liver, with the remainder being distributed throughout the body. It is metabolized in the liver. About 90% of the drug is bound to plasma protein. Although estimates of its biologic half-life vary widely, reasonably constant plasma levels can be maintained with oral administration at 6 hour intervals. The drug is excreted in the urine in an inactive form.

Drug indications

vasospasms

Dosage

Parenteral administration of papaverine hydrochloride in doses of 1 to 4 mL is repeated every 3 hours as indicated. In the treatment of cardiac extrasystoles, 2 doses may be given 10 minutes apart.

Drug contraindications

complete atrioventricular heart block

Side effects

nausea , Headache , constipation , Tachycardia , abdominal pain , rash , flushing , vertigo , Diarrhea , Hypertension , anorexia , malaise , hepatitis , general discomfort , excessive sedation , cirrhosis

Alerts

1-This product is to be used by or under the direction of a physician. 2-Papaverine Hydrochloride is not indicated for the treatment of impotence by intracorporeal injection. The intracorporeal injection of papaverine hydrochloride has been reported to have resulted in persistent priapism requiring medical and surgical intervention. 3-Papaverine Hydrochloride should be used with caution in patients with glaucoma.

Points of recommendation

The medication should be discontinued if hepatic hypersensitivity with gastrointestinal symptoms, jaundice, or eosinophilia becomes evident or if liver function test values become altered.

Pregnancy level

C


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