Drug information of Fibrinogen

Mechanism of effect

Fibrinogen concentrate made from pooled human plasma replaces this protein which is missing or reduced in patients with a congenital fibrinogen deficiency.

Pharmacodynamic

Fibrinogen (coagulation factor I), a protein found in normal plasma, is required to clot blood.

Pharmacokinetics

Vd: 45 to 60 mL/kg (range: 36 to 68 mL/kg),
Half-Life Elimination: 61 to 97 hours (range: 56 to 117 hours); may be decreased in children and adolescents <16 years of age

Drug indications

Congenital fibrinogen deficiency

Dosage

Congenital fibrinogen deficiency: Children, Adolescents, and Adults: IV: Note: Adjust dose based on laboratory values and condition of patient. Maintain a target fibrinogen level of 100 mg/dL until hemostasis is achieved.
When baseline fibrinogen level is known:
Dose (mg/kg) = [Target level (mg/dL) - measured level (mg/dL)] divided by 1.7 (mg/dL per mg/kg body weight)
When baseline fibrinogen level is not known: 70 mg/kg

Drug contraindications

hypersensitivity to drug or its components.

Side effects

nausea , Headache , vomiting , allergic reaction , rash , Dyspnea , Chills , fever , pulmonary embolism , deep vein thrombosis , arterial thrombolic event , Anaphylactic reaction , MI

Interactions

Tranexamic acid

Alerts

1-Hypersensitivity: Hypersensitivity reactions (eg, hives, generalized urticaria, chest tightness, wheezing, hypotension, anaphylaxis) may occur. In the event of hypersensitivity reactions, treatment should be discontinued immediately.
2-Thrombotic events: Thrombosis may occur spontaneously in patients with congenital fibrinogen deficiency with or without fibrinogen replacement therapy. Thromboembolic events have been reported in patients receiving fibrinogen concentrate. Consider potential risk of thrombosis with use; monitor for signs and symptoms of thrombosis.

Points of recommendation

1- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat).
2-Do not mix with other drugs or IV solutions and administer through a separate injection line.
3-Discard partially used vials.

Pregnancy level

C