Drug information of Fibrinogen
Fibrinogen is a man-made form of a protein that occurs naturally in the body and helps the blood to clot.
Fibrinogen is used to treat bleeding episodes in people with a congenital fibrinogen deficiency.
Mechanism of effect
Fibrinogen concentrate made from pooled human plasma replaces this protein which is missing or reduced in patients with a congenital fibrinogen deficiency.
Fibrinogen (coagulation factor I), a protein found in normal plasma, is required to clot blood.
Vd: 45 to 60 mL/kg (range: 36 to 68 mL/kg),
Half-Life Elimination: 61 to 97 hours (range: 56 to 117 hours); may be decreased in children and adolescents <16 years of age
Drug indicationsCongenital fibrinogen deficiency
Congenital fibrinogen deficiency: Children, Adolescents, and Adults: IV: Note: Adjust dose based on laboratory values and condition of patient. Maintain a target fibrinogen level of 100 mg/dL until hemostasis is achieved.
When baseline fibrinogen level is known:
Dose (mg/kg) = [Target level (mg/dL) - measured level (mg/dL)] divided by 1.7 (mg/dL per mg/kg body weight)
When baseline fibrinogen level is not known: 70 mg/kg
Drug contraindicationshypersensitivity to drug or its components.
Side effectsnausea , Headache , vomiting , allergic reaction , rash , Dyspnea , Chills , fever , pulmonary embolism , deep vein thrombosis , arterial thrombolic event , Anaphylactic reaction , MI
1-Hypersensitivity: Hypersensitivity reactions (eg, hives, generalized urticaria, chest tightness, wheezing, hypotension, anaphylaxis) may occur. In the event of hypersensitivity reactions, treatment should be discontinued immediately.
2-Thrombotic events: Thrombosis may occur spontaneously in patients with congenital fibrinogen deficiency with or without fibrinogen replacement therapy. Thromboembolic events have been reported in patients receiving fibrinogen concentrate. Consider potential risk of thrombosis with use; monitor for signs and symptoms of thrombosis.
Points of recommendation
1- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat).
2-Do not mix with other drugs or IV solutions and administer through a separate injection line.
3-Discard partially used vials.