Drug information of Pilocarpine

Pilocarpine


Pilocarpine is used to treat glaucoma and other eye conditions. This medicine is available only with your doctor's prescription.

Mechanism of effect

Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.

Pharmacodynamic

When applied topically to the eye as a single dose it causes miosis, spasm of accommodation, and may cause a transitory rise in intraocular pressure followed by a more persistent fall.

Pharmacokinetics

Onset : 20 min
Peak : 1 h
Duration : 3 to 5 h

Dosage

Usual Adult Dose for Intraocular Hypertension
Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension: One drop of 1%, 2%, or 4% solution applied in the eye(s) up to four times a day
Usual Adult Dose for Glaucoma (Open Angle)
Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension: One drop of 1%, 2%, or 4% solution applied in the eye(s) up to four times a day
Usual Adult Dose for Glaucoma (Narrow Angle)
One drop of the 1% or 2% solution applied in the eye(s) up to three times over a 30-minute period
Usual Adult Dose for Production of Miosis
One drop of 1%, 2%, or 4% solution (or two drops administered five minutes apart) should be applied in the eye(s)
Usual Pediatric Dose for Glaucoma, Intraocular Hypertension, Production of Miosis
Under 2 years:
One drop of 1% solution should be applied in the eye(s) three times a day
2 years or older :
Reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension: One drop of 1%, 2% or 4% solution applied in the eye(s) up to four times a day
Management of Acute Angle-Closure Glaucoma: One drop of the 1% or 2% solution applied in the eye(s) up to three times over a 30-minute period
Prevention of Postoperative Elevated IOP Associated with Laser Surgery: One drop of the 1%, 2% or 4% solution (or two drops administered five minutes apart) should be applied in the eye(s) 15 to 60 minutes prior to surgery.

Alerts

Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug.
Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
Change in eyesight, eye pain, or very bad eye irritation , headache.

Points of recommendation

• Use care when driving at night or doing other tasks in lowered lighting.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using pilocarpine while you are pregnant.
• Tell your doctor if you are breast-feeding.
• Use this medicine as ordered by your doctor. Use for the eye only.
• Wash your hands before and after use.
• Do not touch the container tip to the eye, lid, or other skin.
• After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.
• Use as you have been told, even if your signs get better.

Pregnancy level

C


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