Drug information of Thalidomide

Mechanism of effect

Thalidomide is used to treat and prevent moderate to severe skin lesions caused by leprosy. It is also used together with another medicine called dexamethasone to treatmultiple myeloma (bone marrow cancer)

Pharmacodynamic

Thalidomide is used to treat and prevent moderate to severe skin lesions caused by leprosy. It is also used together with another medicine called dexamethasone to treatmultiple myeloma (bone marrow cancer)

Pharmacokinetics

Thalidomide is used to treat and prevent moderate to severe skin lesions caused by leprosy. It is also used together with another medicine called dexamethasone to treatmultiple myeloma (bone marrow cancer)

Drug indications

multiple myeloma , cutaneous manifestations of erythema nodosum leprosum (ENL)

Dosage

Usual Adult Dose for Multiple Myeloma 200 mg orally once a day with water, preferably at bedtime and at least 1 hour after the evening meal

Drug contraindications

Pregnancy , hypersensitivity to drug or its components.

Side effects

Migraine , nausea , Headache , constipation , Tachycardia , Hematuria , dizziness , vomiting , fatigue , Seizures , rash , Bradycardia , vertigo , Diarrhea , asthenia , neutropenia , leukopenia , anemia , chronic heart failure , cardiac arrhythmias , palpitations , peripheral neuritis , neuropathy , acne , deep vein thrombosis , impotence , anxiety , confusion , vasodilatation , anorexia , somnolence , malaise , Tremor , syncope , agitation , dry skin , nail disorders , Angina pectoris , atrial fibrillation , MI , orthostatic hypotension

Interactions

Amitriptyline , Ethosuximide , Ethinyl estradiol+ drospirenone , Estradiol Valerate , Estrogen cojugated , Pregabalin , Amikacin , Gentamicin , Phenobarbital , Trastuzumab , Dacarbazine , Deferasirox , Doxepin , Raloxifene , Cetuximab , Fluticasone propinate , Methocarbamol , Megestrol , Melphalan , Natalizumab , Hydroxyzine , Chlorambucil , Chlordiaze poxide , Chlorpheniramine , Clozapine , Disulfiram , mercaptopurine , prednisone , Butalbital and Acetaminophen , Clofarabine , Necitumumab , Porfimer , Pralatrexate , Binimetinib , Ramelteon , Secobarbital , Tolcapone , Nelarabine , Clorazepate , Quazepam , Cariprazine , Opium , bazedoxifene/conjugated estrogens , nivolumab , Blonanserin , Meningococcal conjugate vaccine , ethotoin , Remoxipride , calaspargase

Alerts

Thalidomide is used to treat and prevent moderate to severe skin lesions caused by leprosy. It is also used together with another medicine called dexamethasone to treatmultiple myeloma (bone marrow cancer)

Points of recommendation

Thalidomide is used to treat and prevent moderate to severe skin lesions caused by leprosy. It is also used together with another medicine called dexamethasone to treatmultiple myeloma (bone marrow cancer)

Pregnancy level

X

Related drugs

Temozolomide