Drug information of Tetanus immuneglobulin
Mechanism of effect
The immune globulin binds to tetanus toxiod, interfering with the normal interaction of the toxoid with human tissue. This prevents the toxoid from invading the nervous system and producing painful muscle spasms as well as autonomic dysfunction.
The Clostridium tetani bacterium is killed either via antibiotic treatment of the host's immune system and immune globulin-bound toxoid is likely broken down by phagocytic immune cells.
Absorption: Tmax for intramuscular administration is 2 days
Half-life: 23 days
powder for injection (250 units)
Prophylaxis: 250 Units IM (single dose)
Active tetanus: 3000-6000 Units IM
Clean minor wound
# doses unknown or 0-2 doses; toxoid only
>3 doses; toxoid if >10 years ago
All other wounds
# doses unknown or 0-1 doses; toxoid plus IG
2 doses; toxoid, but no IG if wound <24 hours old
>3 doses; toxoid if >5 years ago, and no IG
<7 years old: 4 Unit/kg or 250 Units IM
>7 years old: 250 Units IM (single dose)
Tetanus Treatment3000-6000 Units IM
Side effectsNephrotic syndrome , nausea , vomiting , urticaria , fever , tightness in the chest
InteractionsThymoglubin , secukinumab
Thrombocytopenia or coagulation disorders may contraindicate IM injection
Made from human plasma, small risk of viral transmission through administration
Points of recommendation
Discuss specific use of drug and side effects with patient as it relates to treatment.
- Patient may experience short-term pain (HCAHPS).
- Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat).
Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
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