Drug information of Tetracycline
Mechanism of effect
Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.
Tetracycline is a short-acting antibiotic that inhibits bacterial growth by inhibiting translation.
Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more. 20 - 67% protein bound. Not metabolized. They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form. Half life: 6-12 hours
Drug indicationsHelicobacter pylori Infection , bacterial infection , Pneumonia , Bronchitis , Chlamydia Infection , Acne , Upper Respiratory Tract Infection , Brucellosis
Usual Adult Dose for Acne
500 mg orally twice a day for 2 weeks or more, depending on the nature and severity of the infection
Usual Adult Dose for Bronchitis
500 mg orally every 6 hours for 7 to 10 days, depending on the nature and severity of the infection; may be given for 4 to 5 days a week during winter months as prophylaxis against chronic infectious bronchitis
Usual Pediatric Dose for Bacterial Infection
Above 8 years of age: 25 to 50 mg/kg orally per day divided in 4 equal doses
Drug contraindicationshypersensitivity to drug or its components. , hypersensitive toany other drug in the tetracyclin
Side effectsnausea , Headache , vomiting , Diarrhea , anemia , anorexia , Hypersensitivity , Visual abnormalities
InteractionsAtracurium , Aluminium MGS , ampicillin , Isotretinoin , intralipid , Tamsulosin , Aluminium gel , Bismuth , Piperacillin , Sucralfate , Phenytoin , Magnesium oxide , Magnesium sulfate , Trazodone , Tretinoin , Sodium bicarbonate , Succinylcholine , Methotrexate , acitretin , Hematogol , Cloxacillin , Cholestyramine , Zincola , fentanyl , Pancuronium , Ethinyl Estradiol , Axitinib , Phenindione , Calcium citrate , Succinylcholine Chloride , Oxacillin , Mitiglinide , Magnesium hydroxide , Iron , Iron polysaccharide , carbonyl iron , aminolevulinic acid oral , Aminolevulinic acid topical , Aluminium Mg , Flibanserin , Entrectinib , cholera vaccine live , atovaquone/proguanil , Methyl aminolevulinate , magnesium chloride , Biolectra Magnesium , Iron Dextran Complex , Remdesivir , Cannabidiol , magnesium citrate , Typhoid vaccine (live), oral , Bacampicillin
1-THE USE OF DRUGS OF THE Tetracycline CLASS DURING TOOTH DEVELOPMENT (LAST HALF OF PREGNANCY, INFANCY AND CHILDHOOD TO THE AGE OF 8 YEARS) MAY CAUSE PERMANENT DISCOLORATION OF THE TEETH .
2-If renal impairment exists, even usual oral or parenteral doses may lead to excessive systemic accumulation of the drug and possible liver toxicity.
Points of recommendation
• Avoid milk, calcium containing dairy products, iron, antacids, or aluminium salts 2 hours before or 6 hours after using antacids while on this medication.
• Take on empty stomach: 1 hour before or 2 hours after meals.
• Take with a full glass of water.
• Patients on tetracycline therapy should minimize exposure to direct sunlight and other sources of ultraviolet radiation, and to use sunscreens and other protection whenever prolonged exposure is unavoidable