Drug information of Triplesulfa


Drug group: sulfonamide

Triple sulfa is a name used for the combination of three sulfa antibiotic drugs - sulfacetamide , sulfathiazole, and sulfabenzamide. It is an antibacterial medication that fights bacteria in the body.

Mechanism of effect

Sulfonamides are broad-spectrum, bacteriostatic anti-infectives. They are structural analogs of para-aminobenzoic acid (PABA) and competitively inhibit a bacterial enzyme, dihydropteroate synthetase, that is responsible for incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid.
This blocks the synthesis of dihydrofolic acid and decreases the amount of metabolically active tetrahydrofolic acid, a cofactor for the synthesis of purines, thymidine, and DNA.


Sulfa antibiotics work by slowing the growth of bacteria, in this case on the skin surfaces of the vagina.


Sulfonamides are absorbed through the vaginal mucosa.


Usual adult and adolescent dose (vaginal cream)
Intravaginal, 1 applicatorful (approximately 6 grams) one or two times a day for four to ten days.
Usual adult and adolescent dose ( vaginal suppository)
Intravaginal, 1 suppository one or two times a day for ten days.


• Patients sensitive to one sulfonamide may be sensitive to other sulfonamides also.
Patients sensitive to furosemide, thiazide diuretics, sulfonylureas, or carbonic anhydrase inhibitors may be sensitive to sulfonamides also.
• Use of topical sulfonamides may lead to sensitization, resulting in hypersensitivity reactions with subsequent topical or systemic use of the medication.
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency (hemolytic anemia may occur in G6PD-deficient patients)
• Hepatic function impairment (sulfonamides are metabolized in the liver; may cause hyperbilirubinemia in nursing infants)
Porphyria (sulfonamides may precipitate an acute attack of porphyria)

Points of recommendation

• Do not use triple sulfa vaginal if you have ever had an allergic reaction to it or to another sulfa-based medicine.
• Triple sulfa vaginal is in the FDA pregnancy category C. This means that it is not known whether triple sulfa vaginal will be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant.
Triple sulfa passes into breast milk and may affect a nursing baby. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.
• Use this medication for the full amount of time prescribed by your doctor or recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.
• Avoid wearing tight-fitting, synthetic clothing (such as pantyhose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.
• Avoid getting this medication in the eyes, nose, or mouth.
• Avoid sexual intercourse or use a condom to prevent spreading the infection to a sexual partner.
• Apply the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and apply only the next regularly scheduled dose. Do not use a double dose.

Pregnancy level


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