Drug information of Trimipramine
Mechanism of effect
The mode of action of trimipramine maleate capsules on the central nervous system is not known. However, unlike amphetamine-type compounds it does not act primarily by stimulation of the central nervous system. It does not act by inhibition of the monoamine oxidase system.
Trimipramine maleate capsules are an antidepressant with an anxiety-reducing sedative component to its action.
Rapid absorption. Protein binding:93%-96% (to plasma proteins). Metabolism:Hepatic. Half life:11-18 hrs
Usual Adult Dose for Depression Outpatients: Initial dose: 75 mg orally per day in divided doses Maintenance dose: 50 to 150 mg orally per day Maximum Dose: 200 mg orally per day Hospitalized patients: Initial dose: 100 mg orally per day in divided doses Maintenance dose: 200 mg orally per day Maximum Dose: 300 mg orally per day
Drug contraindicationshypersensitivity to drug or its components. , Concomitant with MAOIs , Myocardial infarction
Side effectsnausea , Tachycardia , vomiting , rash , Diarrhea , urticaria , Hypertension , hypotension , cardiac arrhythmias , palpitations , anxiety , confusion , anorexia , Tremor , agitation , ataxia , MI , petechiae , hallucinations , Facial edema
InteractionsErgotamine-C , Octreotide acetate , Expectorant , Imatinib , Paroxetine , Pimozide , Huperzine A , Arformoterol , Benzphetamine , Milnacipran , acrivastine+pseudoephedrine , Halofantrine , Grepafloxacin , Dexfenfluramine , chlorcyclizine + phenylephrine , Peginterferon alfa-2b , pilocarpine oral , Arsenic trioxide , Desvenlafaxine , Xylometazoline , Propylhexedrine , vandetanib , Droperidol , Procainamide , Mefloquine , Indapamide , lisdexamfetamine , Sodium Oxybate , Tapentadol , safinamide , rasagiline , Diethylpropion , Palonosetron , Venlafaxine , Chlordiaze poxide , Clozapine , Yohimbine , Cyclobenzaprine , potassium citrate , Citalopram , Cisapride , Fluticasone propinate , Fluoxetine , Levofloxacin , Moxifloxacin , Zolpidem , Salbutamol , Sunitinib , Sertraline , Sotalol , Sibutramine , Trazodone , Tranylcypromine , Duloxetine , Dobutamine , Domperidone , Doxepin , Cimetidine
1-Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. 2-It should be noted that trimipramine maleate capsules are not approved for use in treating bipolar depression. 3-The pupillary dilation that occurs following use of many antidepressant drugs including trimipramine maleate capsules may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy.
Points of recommendation
1-Trimipramine maleate capsules should be used with caution in patients with impaired liver function 2-Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down