Drug information of Tinidazole

Tinidazole

Drug group:

Tinidazole is an antiprotozoal and antibiotic . It works by killing sensitive parasites and bacteria.

Mechanism of effect

Tinidazole is in a class of medications called antiprotozoal agents. It works by killing the organisms that can cause infection.

Pharmacodynamic

Antiprotozoal ; may cause cytotoxicity by damaging DNA and preventing further DNA synthesis

Pharmacokinetics

Half-life : 12-14 hr
Metabolism : Mainly by CYP3A4
Vd : 50L
Protein binding : 12%
Peak plasma time : 1.6 hr
Metabolites : Undergoes oxidation, hydroxylation & conjugation
Excretion : Mainly in urine (20-25% as unchanged drug); feces: 12%

Dosage

Amebiasis, Intestinal : 2 g/day PO for 3 days
Amebic Liver Abscess : 2 g/day PO for 3-5 days
Giardiasis or Trichomoniasis : 2 g PO once
Bacterial Vaginosis (Nonpregnant) : 2 g PO qDay for 2 days OR 1 g PO qDay for 5 days

Alerts

• Risk of bacterial overgrowth with prolonged treatment
• No safety & efficacy data on pediatric patients <3 years of age
• Not studied for bacterial vaginosis in pregnant women
• Caution in patients with history of blood dyscrasias or history of hepatic impairment
• Risk of convulsive seizures & peripheral neuropathy - caution in neurologically compromised patients
• For trichomoniasis, treat sexual partners concurrently with same dose

Points of recommendation

• Take tinidazole by mouth with food.
• If you have trouble swallowing the tablets, check with your doctor or pharmacist.
• If you take cholestyramine, do not take it at the same time you take tinidazole. Talk with your doctor about how you should take cholestyramine with tinidazole.
• If more than one dose of tinidazole is required, continue using tinidazole for the full course of treatment in order to clear up your infection completely, even if you feel better in a few days. Do not miss any doses.
• Tinidazole may discolor or darken the urine. This is normal and not a cause for concern.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using tinidazole. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Pregnancy level

C

Related drugs

Metronidazole , Nitazoxanide


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