Drug information of ritodrine
Mechanism of effect
Ritodrine is beta-2 adrenergic agonist. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a decrease of uterine contractions.
Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist
Protein binding: ~56%. Metabolism: Hepatic, by both the mother and fetus. Half life: 1.7-2.6 hours.
Drug indicationsstop premature labor
• For oral dosage form (extended-release capsules):
o Adults: In the first twenty-four hours after the doctor stops your intravenous ritodrine, your dose may be as high as 40 milligrams (mg) every eight hours. After that, the dose is usually 40 mg every eight to twelve hours. Your doctor may want you to take oral ritodrine up until it is time for you to deliver your baby or until your 37th week of pregnancy.
• For oral dosage form (tablets):
o Adults: In the first twenty-four hours after the doctor stops your intravenous ritodrine, your dose may be as high as 10 milligrams (mg) every two hours. After that, the dose is usually 10 to 20 mg every four to six hours. Your doctor may want you to take oral ritodrine up until it is time for you to deliver your baby or until your 37th week of pregnancy.
• For injection dosage form:
o Adults: 50 to 350 micrograms per minute, injected into a vein.
hypersensitivity to drug or its components. , eclampsia , preeclampsia , Abnormal uterine bleeding , Intrauterine Fetal Death
nausea , Headache , chest pain , Tachycardia , vomiting , rash , flushing , cardiac arrhythmias , anxiety , Tremor , Hypokalemia , sweating , pulmonary edema , Abnormal uterine bleeding
InteractionsTriamcinolone NN , Atenolol , Propranolol , Tranylcypromine , Sotalol , Labetalol , Metoprolol , Moclobemide , Carvedilol , Bisoprolol , Linezolid , Levobunolol , Dolasetron , vandetanib , Dofetilide , Halofantrine , Grepafloxacin , Carteolol , Bendroflumethiazide , Bepridil , bedaquiline
Make sure you tell your doctor if you have any other medical problems, especially: Diabetes, High blood pressure (hypertension), uncontrolled, Migraine headaches, Heart or blood vessel disease , Overactive thyroid, uncontrolled.
Points of recommendation
1-Check with your doctor right away if your contractions begin again or your water breaks
2- Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines