Drug information of Clofazimine

Clofazimine

Drug group:

Clofazimine is taken to treat leprosy (Hansen's disease). It is sometimes given with other medicines for leprosy. When clofazimine is used to treat ``flare-ups'' of leprosy, it may be given with a cortisone-like medicine. Clofazimine may also be used for other problems as determined by your doctor.

Mechanism of effect

Clofazimine exerts a slow bactericidal effect on Mycobacterium leprae (Hansen's bacillus). Clofazimine inhibits mycobacterial growth and binds preferentially to mycobacterial DNA. It may also bind to bacterial potassium transporters, thereby inhibiting their function. Lysophospholipids have been found to mediate the activity of this drug.

Pharmacodynamic

Clofazimine exerts a slow bactericidal effect on Mycobacterium leprae (Hansen's bacillus). Clofazimine inhibits mycobacterial growth and binds preferentially to mycobacterial DNA. Clofazimine also exerts antiinflammatory properties in controlling erythema nodosum leprosum reactions.
Clofazimine is highly lipophilic and tends to be deposited predominantly in fatty tissue and in cells of the reticuloendothelial system. It is taken up by macrophages throughout the body. Measurement of the minimum inhibitory concentration (MIC) of clofazimine against leprosy bacilli in vitro is not yet feasible.

Pharmacokinetics

Incompletely absorbed from GI tract following oral administration.When clofazimine capsules are used, 45-70% of dose is absorbed.Peak serum concentrations usually attained within 4-12 hours when dose is given with food.Food increases rate and extent of absorptionTissue half-life following multiple oral doses is estimated to be ≥70 days..

Dosage

Adults:
50mg
Pediatric:
Safety and efficacy not established

Alerts

The presence of other medical problems may affect the use of clofazimine. Make sure you tell your doctor if you have any other medical problems, especially:
Liver disease—Clofazimine may on rare occasion cause hepatitis and liver disease
Stomach or intestinal problems, Clofazimine often causes some stomach upset, but on rare occasion may cause severe, sharp abdominal pain and burning, which may be a sign of a serious side effect
Pink to brownish-black discoloration of skin occurs in most patients.Dryness, burning, itching, irritation, and watering of the eyes also reported.Safety and efficacy not established in children.

Points of recommendation

Importance of taking with meals.Importance of taking only as prescribed; do not increase dosage or duration of therapy unless otherwise instructed by a clinician.

Pregnancy level

C

Related drugs

Dapsone , Capreomycin , Pyrazinamide


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