Drug information of Linezolid
Mechanism of effect
Linesilid bind to the 50S subunit of the prokaryotic ribosome, preventing formation of the initiation complex for protein synthesis
Linezolid , the first of a new class of antibiotics , the oxazolidinones, is approved for treatment of Gram-positive bacterial infections, including resistant strains.
urine is a major route of excretion of linezolid
600 mg PO/IV every 12 hours , 10 to 14 days
Side effectsnausea , Headache , insomnia , constipation , dizziness , vomiting , Diarrhea , fever , Increased ALT , skin rush , Leukopenia
InteractionsAmitriptyline , Ergotamine-C , Oxecarbazepin , Expectorant , Brimonidine , Bupivacaine , Buspirone , Pseudoephedrine , Tetrabenazine , Trazodone , Tramadol , Deferiprone , Doxepin , Sibutramine , Cyproheptadine , Citalopram , Fluvoxamine , Methyl phenidate , Modafinil , ritodrine , fentanyl , Cyclobenzaprine , ampicillin , Imipenem , Rifampin , Vancomycin , Buprenorphine , Phenelzine , Tapentadol , Pethidine , safinamide , methylene blue , rasagiline , Pentazocine , Almotriptan , Diethylpropion , eletriptan , Phenylpropanolamine , Dolasetron , Palonosetron , apraclonidine , Sufentanil , Alfentanil , lisdexamfetamine , Lorcaserin , Doxapram , Alphagan , L-Tryptophan , Desvenlafaxine , Xylometazoline , Propylhexedrine , Milnacipran , acrivastine+pseudoephedrine , Doxylamine , Dexfenfluramine , chlorcyclizine + pseudoephedrine , chlorcyclizine + phenylephrine , Arformoterol , Butorphanol , Benzphetamine , Acetaminophen and benzhydrocodone , Dipipanone , Difenoxin , cholera vaccine live , Levalbuterol , Cordyceps , Oxymorphone , Levomilnacipran , Guanadrel , 5-hydroxytryptophan , Ethchlorvynol , entacapone , phendimetrazine , lasmiditan , Typhoid vaccine (live), oral , nalbuphine , chlorcyclizine , Nesiritide
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking linezolid and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Eating tyramine while you are using linezolid can raise your blood pressure to dangerous levels. Avoid foods that have a high level of tyramine, such as:
aged cheeses or meats;
pickled or fermented meats, smoked or air-dried meats;
tap beer (alcoholic and nonalcoholic);
red wine; or
any meat, cheese, or other protein-based food that has been improperly stored. You should become very familiar with the list of foods you must avoid while you are using linezolid.
Points of recommendation
You should not use Linesolide if you have untreated or uncontrolled high blood pressure, a carcinoid tumor, adrenal gland tumor, or a severely overactive thyroid. If you take an antidepressant or psychiatric medication, call your doctor right away if you have signs of a serious drug interaction, including: confusion, memory problems, feeling hyperactive (mentally or physically), loss of coordination, muscle twitching, shivering, sweating, diarrhea, and/or fever.
Eating tyramine while you are using linezolid can raise your blood pressure to dangerous levels. Avoid foods that have a high level of tyramine, such as aged cheeses or meats, pickled or fermented meats, smoked or air-dried meats, sauerkraut, soy sauce, tap beer, red wine, or any meat, cheese, or other protein-based food that has been improperly stored.