Drug information of Teicoplanin | Targocid
Teicoplanin | Targocid
Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis.
It is a glycopeptideantiobiotic extracted from Actinoplanesteichomyceticus , with a similar spectrum of activity to vancomycin
Mechanism of effect
Its mechanism of action is to inhibit bacterial cell wall synthesis.
Teicoplanin inhibits peptidoglycan polymerization, resulting in inhibition of bacterial cell wall synthesis and cell death
Targocid 400mg injection is an antibiotic. It kills the bacteria by attacking their cell wall. Specifically, it prevents the synthesis of a substance in the cell wall called peptidoglycan , which provides the cell wall with the strength required for survival of bacteria in human body.
• Absorption: Teicoplanin is poorly absorbed after oral administration but is 90% bioavailable when administered intramuscularly. Peak plasma concentrations: 1 hr (IV); 2-4 hr (IM).
• Half life: 70-100 hours
• Distribution: Protein binding: 90-95%. Poor penetration into the CSF. It is taken up into white blood cells.
• Excretion: Excreted unchanged via urine (97%).
• Elimination: Unchanged teicoplanin is mainly excreted by urinary route (80% within 16 days) while 2.7% of the administered dose is recovered in feces (via bile excretion) within 8 days following administration.
• Severe Gram-positive infections
Adult: Initially, 6 mg/kg on first day, followed by 3 mg/kg/day. Severe infection: 6 mg/kg every 12 hr for the 1st 3 doses followed by 6 mg/kg/day. Doses may be given via IM inj, IV bolus or IV infusion over 30 minutes.
Loading dose: 10 mg/kg every 12 hr for 3 doses followed by 6-10 mg/kg/day depending on severity of the infection. Neonates: Loading dose: 16 mg/kg on the 1st day, followed by maintenance doses of 8 mg/kg/day by IV infusion.
• Prophylaxis of Gram-positive infection in high-risk patients undergoing surgery
Adult: 400 mg as single dose at induction of anesth.
Drug contraindicationshypersensitivity to drug or its components.
Side effectsnausea , Headache , vomiting , vertigo , Diarrhea , fever , Anaphylactic reaction , gastrointestinal disturbances , Leukopenia , tinnitus , Rash , local thrombophlebitis , Nephrotoxicity , ototoxicity , Pain at site of admin
InteractionsAmphotericin B , Cisplatin , BCG vaccine , Typhoid vaccine (live), oral
Hypersensitivity to Targocid Injection is a contraindication. In addition, Targocid Injection should not be used if you have the following conditions:
• Kidney problems
• Low platelet count
• Red man syndrome
Points of recommendation
Let your physicion know if there is any of below conditions:
Preexisting renal insufficiency, hypersensitivity to vancomycin . Perform periodic haematological studies, renal, LFT. Pregnancy, lactation.
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