Drug information of Methazolamide

Methazolamide

Drug group:

A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Mechanism of effect

Methazolamide is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.

Pharmacodynamic

Methazolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Although methazolamide achieves a high concentration in the cerebrospinal fluid, it is not-considered an effective anticonvulsant. Methazolamide has a weak and transient diuretic effect, therefore use results in an increase in urinary volume, with excretion of sodium, potassium and chloride.

Pharmacokinetics

Methazolamide is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.

Dosage

Methazolamide is a potent inhibitor of carbonic anhydrase. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.

Side effects

dizziness , vomiting , anorexia

Alerts

COPD, emphysema, concomitant high-dose aspirin or steroid therapy, or hepatic insufficiency

ADRs common to sulfonamide derivatives

Stevens-Johnson syndrome and toxic epidermal necrolysis may occur

Points of recommendation

  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how methazolamide affects you.
  • Have your eye pressure and eyesight checked as you have been told by the doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take methazolamide.
  • This medicine may make you sunburn more easily. Use care if you will be in the sun. Tell your doctor if you sunburn easily while taking this drug.
  • If you are also taking aspirin, talk with your doctor. Loss of hunger, fast breathing, sluggishness, coma, and death have happened in people taking high doses of aspirin with methazolamide.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using methazolamide while you are pregnant.
  • To gain the most benefit, do not miss doses.
  • Keep taking methazolamide as you have been told by your doctor or other health care provider, even if you feel well.
  • This medicine may cause you to pass urine more often. To keep from having sleep problems, try to take before 6 pm.
  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

Pregnancy level

C

Related drugs

Acetazolamide , Dorzolamide


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