Drug information of Flubendazole


Drug group:

Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.

Mechanism of effect

Flubendazole inhibits cytoplasmic microtubules in the intestinal or absorptive cells of the worms, thus inhibiting glucose uptake and glycogen storage depletion, leading to death of the worms within days.


Not Available


Absorption: flubendazole is poorly absorbed after oral administration.

Elimination: plasmatic rates and urinary elimination are negligible and most of the taken dose is excreted in the faeces and unchyanged drug or primary metabolites.

Drug indications

Flubendazole is a member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections. It has a role as an antinematodal drug and a teratogenic agent


Adult : PO Enterobiasis 100 mg as a single dose. Repeat 2-3 wk later if needed. Ascariasis; Hookworm infections; Trichuriasis 100 mg twice daily for 3 days.

Drug contraindications


Side effects

GI disturbances; headache, dizziness; allergic reactions; raised liver enzyme values; alopoecia; bone marrow suppression


Enzyme inducers eg phenytoin or carbamazepine; and inhibitors eg cimetidine.


A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications

Points of recommendation

A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs

Pregnancy level


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