Drug information of Pindolol
Pindolol is a moderately lipophilic beta blocker (adrenergic beta-antagonists) . that has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. it causes Lowering high blood pressure and helps prevent strokes and heart attacks.
It works by blocking the effects of certain natural substances (such as epinephrine and adrenalin) on the heart and blood vessels. This results in a lowering of the heart rate, blood pressure, and strain on the heart.
Mechanism of effect
Non-selective beta adrenergic receptor with mild sympathomimetic activity; has negative inotropic and chronotropic effects and can significantly slow AV nodal conduction.
Pindolol is a non-selective beta blocker or β-adrenergic receptor antagonist with partial agonist activity.
Protein Bound: 40%
Peak Plasma (single 20 mg dose) Time: 1 hr
Half-Life: 3-4 hr in healthy adults
Metabolism: 60-65% in liver
Excretion: Urine (35-40% as unchanged drug); feces (6-9%)
Drug indicationsVentricular Tachycardia
5 mg PO q12hr initially; may increase by 10 mg/day q3-4wk to up to 30 mg PO q12hr
Chronic Stable Angina (Off-label):
15-40 mg/day PO divided q6-8hr
Drug contraindicationsAsthma , cardiac failure , sinus bradycardia , hypersensitivity to this drug , Chronic obstructive pulmonary disease
Side effectsAnxiety , Diarrhea , edema , nausea , dizziness , vomiting , impotence , Arthralgia , decreased libido , tiredness , increased liver enzymes in the blood , Abdominal discomfort
InteractionsThioridazine , Drospirenone , Doxazosin , Atenolol , Alprazolam , Amiodarone , Epinephrine , Prazosin , Diphenhydramin , Hydrocodone , Clonidine , codeine , Fenoldopam , Arbutamine , Carisoprodol , Zolpidem , Cetirizine , Fingolimod , Lorazepam , Methyldopa , Chlorpromazine , Dolasetron , Penbutolol , lipiodol , Nebivolol , Arformoterol , Bitolterol , ProHance , Treprostinil , Olodaterol , umeclidinium bromide/vilanterol inhaled , Oxtriphylline
Use caution in anesthesia/surgery, bronchospastic disease, cerebrovascular insufficiency, chronic heart failur, cardiomegaly, diabetes mellitus, hyperthyroidism/thyrotoxicosis, myasthenia gravis, liver disease, renal impairment, peripheral vascular disease, pheochromocytoma, history of psychiatric disease.
Sudden discontinuation can exacerbate angina and lead to myocardial infarction.
Pindolol is not approved for use by anyone younger than 18 years old.
Points of recommendation
Discuss specific use of drug and side effects with patient.
Take this medication by mouth with or without food, usually twice daily or as directed by your doctor.
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