Drug information of Diclofenac

Diclofenac

Drug group:

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine
works by reducing substances in the body that cause pain and inflammation. Diclofenac is used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis.

Mechanism of effect

The mechanism of action of Diclofenac Sodium Extended-release Tablets, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.

Pharmacodynamic

Diclofenac Sodium Extended-release Tablets are a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models

Pharmacokinetics

Completely absorbed from the gastrointestinal tract. Diclofenac is more than 99% bound to human serum proteins, primarily to albumin.
Metabolism:Hepatic Approximately 65% of the dose is excreted in the urine and approximately 35% in the bile as conjugates of unchanged Diclofenac plus metabolites.

Drug indications

Migraine , Pain

Dosage

Usual Adult Dose for Osteoarthritis Diclofenac free acid capsules:
35 mg orally 3 times a day
Diclofenac potassium immediate-release tablets: 50 mg orally 2 or 3 times a day
Diclofenac sodium enteric-coated tablets: 50 mg orally 2 or 3 times a day or 75 mg orally 2 times a day
Maximum dose: 150 mg daily
Diclofenac sodium extended-release tablets: 100 mg orally once a day
Usual Adult Dose for Pain
Oral:
Diclofenac potassium liquid-filled capsules: 25 mg orally 4 times a day Diclofenac free acid capsules: 18 mg or 35 mg orally 3 times a day
Diclofenac
potassium immediate-release tablets: 50 mg orally 3 times a day; an initial dose of 100 mg orally followed by 50 mg oral doses may provide better relief in some patients.
Parenteral: 37.5 mg IV bolus over 15 seconds every 6 hours as needed for pain Maximum Dose: 150 mg per day

Alerts

1-To minimize the potential risk for an adverse CV event in patients treated with an NSAID, the lowest effective dose should be used for the shortest duration possible.
2-Patients and physicians should remain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapy and promptly initiate additional evaluation and treatment if a serious GI adverse event is suspected.
3-If Diclofenac Sodium Extended-release Tablets therapy must be initiated, close monitoring of the patient's renal function is advisable.
4-Of the markers of hepatic function, ALT (SGPT) is recommended for the monitoring of liver injury.
5-NSAIDs, including Diclofenac Sodium Extended-release Tablets, can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal.

Points of recommendation

1-In late pregnancy, as with other NSAIDs, Diclofenac Sodium Extended-release Tablets should be avoided because it will cause premature closure of the ductus arteriosus.
2-Take with food to reduce irritation.

Pregnancy level

C


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