Drug information of Rabeprazole

Rabeprazole


Rabeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Rabeprazole is used short-term to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children who are at least 1 year old.
Rabeprazole is used only in adults to treat conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome. Rabeprazole is also used in adults to promote healing of duodenal ulcers or erosive esophagitis (damage to your esophagus caused by stomach acid).
Rabeprazole may also be given with an antibiotic to prevent duodenal ulcer caused by infection with Helicobacter pylori (H. pylori). Rabeprazole is not for immediate relief of heartburn symptoms.

Mechanism of effect

Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell.

Pharmacodynamic

Rabeprazole prevents the production of acid in the stomach. By acting specifically on the proton pump, Rabeprazole blocks the final step in acid production, thus reducing gastric acidity.

Pharmacokinetics

Absolute bioavailability is approximately 52%. 96.3% (bound to human plasma proteins) .
Following a single 20 mg oral dose of 14C-labeled rabeprazole, approximately 90% of the drug was eliminated in the urine, primarily as thioether carboxylic acid; its glucuronide, and mercapturic acid metabolites.
Half life: 1-2 hours (in plasma).

Dosage

Usual Adult Dose for Duodenal Ulcer
Recommended dose: 20 mg orally once a day
Duration of therapy: 4 weeks
Usual Adult Dose for Erosive Esophagitis
Recommended dose: 20 mg orally once a day
Duration of therapy: 4 to 8 weeks
Usual Adult Dose for Gastric Ulcer
Recommended dose: 20 mg orally once a day
Duration of therapy: 4 to 8 weeks
Usual Adult Dose for Duodenal Ulcer Prophylaxis
Recommended dose: 20 mg orally once a day
Duration of therapy: 12 months
Usual Adult Dose for Gastroesophageal Reflux Disease
Recommended dose: 20 mg orally once a day
Duration of therapy: Up to 4 weeks
Usual Adult Dose for Helicobacter pylori Infection
Recommended dose: 20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin
Duration of therapy: 7 days
Usual Adult Dose for Zollinger-Ellison Syndrome
Initial dose: 60 mg orally once a day
Maintenance dose: 60 mg orally 2 times a day or 100 mg orally once a day
Duration of therapy: Up to 1 year
Usual Pediatric Dose for Gastroesophageal Reflux Disease
1 to 11 years:
Less than 15 kg: 5 mg orally once a day for up to 12 weeks with the option to increase to 10 mg if inadequate response
15 kg or more: 10 mg orally once a day for up to 12 weeks
12 years or older:
20 mg orally once a day for up to 8 weeks

Alerts

1-Symptomatic response to therapy with Rabeprazole does not preclude the presence of gastric malignancy.
2-Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Rabeprazole.
3-Acute interstitial nephritis has been observed in patients taking PPIs including Rabeprazole.
4-Daily treatment with any acid-suppressing medications over a long period of time (e.g., longer than 3 years) may lead to malabsorption of cyanocobalamin (vitamin B-12) caused by hypo-or achlorhydria.

Points of recommendation

• Take without regard to meals.

Pregnancy level

B


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