Drug information of cortisone

Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability

Metabolism
Hepatic to active metabolite hydrocortisone (cortisol)
Distribution
Distributes to muscles, liver, skin, intestines, and kidneys
Absorption
Readily
Excretion
Urine and feces
Time to Peak
~2 hours
Half life
~0.5 hours

Allergic states
Dermatologic diseases
Endocrine disorders
Gastrointestinal diseases
Hematologic disorders
Neoplastic diseases
Ophthalmic diseases
Renal diseases
Respiratory diseases
Rheumatic disorders
Miscellaneous

Usual Adult Dose for Adrenal Insufficiency
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Idiopathic (Immune) Thrombocytopenic Purpura
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Shock
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Hemolytic Anemia
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Erythroblastopenia
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Loeffler's Syndrome
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Sarcoidosis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Berylliosis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Lymphoma
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Nephrotic Syndrome
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Uveitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Iritis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Keratitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Conjunctivitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Iridocyclitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Chorioretinitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Choroiditis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Systemic Lupus Erythematosus
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Dermatomyositis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Ankylosing Spondylitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Bursitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Osteoarthritis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Rheumatoid Arthritis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Gouty Arthritis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Psoriatic Arthritis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Epicondylitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Dermatitis Herpetiformis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Psoriasis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Seborrheic Dermatitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Pemphigus
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Erythema Multiforme
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Allergic Rhinitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Atopic Dermatitis
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Asthma
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Serum Sickness
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Ulcerative Colitis - Active
Initial dose: 25 to 300 mg per day
Usual Adult Dose for Tuberculous Meningitis
Initial dose: 25 to 300 mg per day

Systemic fungal infections
Hypersensitivity to this product

>10%
Central nervous system: Insomnia, nervousness
Gastrointestinal: Dyspepsia, increased appetite
1%
 to 10%
Endocrine & metabolic: Diabetes mellitus, hirsutism
Neuromuscular & skeletal: Arthralgia
Ophthalmic: Cataract, glaucoma
Respiratory: Epistaxis

Acetylcholinesterase Inhibitors, Aldesleukin, Amezinium, Amphotericin B, Androgens, Antacids, Antidiabetic Agents, Aprepitant, Axicabtagene Ciloleucel, Baricitinib, BCG (Intravesical), Bile Acid Sequestrants, Calcitriol (Systemic), Cladribine, Coccidioides immitis Skin Test, Corticorelin, Cosyntropin, CYP3A4 Inducers (Strong), CYP3A4 Inhibitors (Strong),
Deferasirox, Denosumab, Desirudin, Desmopressin, DilTIAZem, Echinacea, Estrogen Derivatives, Fexinidazole [INT], Fingolimod, Fosaprepitant, Hyaluronidase, Indacaterol,
Indium 111 Capromab Pendetide, Isoniazid, Leflunomide, Loop Diuretics, Macimorelin,
Mifamurtide, MiFEPRIStone, Mitotane, Natalizumab, Neuromuscular-Blocking Agents (Nondepolarizing), Nicorandil, Nivolumab, Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective), Nonsteroidal Anti-Inflammatory Agents (Nonselective), Ocrelizumab, Ozanimod,
Pidotimod, Pimecrolimus, Quinolones, Ritodrine, Roflumilast, Salicylates, Sargramostim,
Siponimod, Sipuleucel-T, Somatropin, Tacrolimus (Systemic), Tacrolimus (Topical),
Tertomotide, Tesamorelin, Thiazide and Thiazide-Like Diuretics, Tisagenlecleucel,
Tofacitinib, Trastuzumab, Upadacitinib, Urea Cycle Disorder Agents, Vaccines (Inactivated),
Vaccines (Live), Vitamin K Antagonists (eg, warfarin)

You should not use this medication if you are allergic to cortisone, or if you have a fungal infection anywhere in your body

Steroid medication can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Before taking this medication, tell your doctor about any illness or infection you have had within the past several weeks

Do not stop using cortisone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication

An overdose of cortisone is not expected to produce life threatening symptoms. However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

Avoid drinking alcohol while you are taking cortisone

Before taking cortisone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids

Your dosage needs may change if you have surgery, are ill, are under stress, or have a fever or infection. Do not change your medication dose or schedule without your doctor's advice. Tell your doctor about any illness or infection you have had within the past several weeks

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using a steroid

Do not receive a "live" vaccine while using cortisone. The vaccine may not work as well during this time, and may not fully protect you from disease

Do not stop using cortisone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication

Wear a medical alert tag or carry an ID card stating that you take cortisone. Any medical care provider who treats you should know that you take steroid medication

To make sure you can safely take cortisone, tell your doctor if you have any of these other conditions:
-liver disease (such as cirrhosis)
-kidney disease
-a thyroid disorder
-diabetes
-a history of malaria
-tuberculosis
-osteoporosis
-a muscle disorder such as myasthenia gravis
-glaucoma or cataracts
-herpes infection of the eyes
-stomach ulcers, ulcerative colitis, or diverticulitis
-depression or mental illness
-congestive heart failure
-high blood pressure

Steroids can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using cortisone

not available