Drug information of Diethylpropion
Mechanism of effect
Diethylpropion is a sympathomimetic stimulant drug marketed as an appetite suppressant. Chemically, it is the N,N-diethyl analog of cathinone. Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine.
- Metabolism: Undergoes reduction and N-dealkylation to form active metabolites
- Duration: 4 hr
- Half-life elimination: 4-6 hr (aminoketone metabolites)
- Excretion: primarily urine (>75%)
- 25 mg PO q8hr 1 hour AC
- May add 1 additional 25 mg dose PO midevening to overcome night hunger
- 75 mg PO qDay, swallowed whole, in midmorning
- Safety & efficacy not established
> 16 years
- Immediate release: 25 mg PO q8hr AC
- Controlled release: 75 mg PO qDay, swallowed whole, in midmorning
Side effectsPain , Insomnia , Headache , nausea , dry mouth , dizziness , vomiting , Blurred vision , urticaria , Hypertension , palpitations , impotence , Restlessness , Rash
InteractionsErgotamine-C , Sibutramine , Tapentadol , Amitriptyline , Isoflurane , Imipramine , Procarbazine , Trazodone , Tranylcypromine , Ergoloid Mesylate , Dosulepin , Mianserin , lofepramine , isocarboxazid , safinamide , protriptyline , Methoxyflurane , Enflurane , Doxapram , ergotamine , ergonovine , Linezolid , Phenelzine , Desflurane , Amoxapine , Maprotiline , Methylergonovin , Nortriptyline , Cabergoline , Clomipramine , Yohimbine , Trimipramine , Desipramine , Doxepin , Dihydroergotamine , Selegiline , Sevoflurane , Phenylpropanolamine , Dexfenfluramine , Levomilnacipran
- Discontinue when tolerance develops - DO NOT EXCEED recommended dose
- Pregnancy, lactation
- Use caution in patients with diabetes mellitus or Tourette's syndrome
- Incidence of primary pulmonary hypertension has been associated with therapy use
- Mild hypertension, symptomatic cardiovascular disease
- Development of valvular heart disease reported
- May impair ability to drive &/or operate heavy machinery
Points of recommendation
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Diethylpropion may be habit-forming. Never share diethylpropion with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.
The immediate-release diethylpropion tablet is usually taken three times a day before meals.
The extended-release diethylpropion tablet is usually taken once a day midmorning.
Tell your doctor if you do not lose at least 4 pounds after taking the medicine for 4 weeks along with a low calorie diet.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
If you need surgery, tell the surgeon ahead of time that you are using diethylpropion. You may need to stop using the medicine for a short time.
Do not stop using diethylpropion suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.