Drug information of Emedastine

Mechanism of effect

Emedastine is a relatively selective, histamine H₁ antagonist. In vivo studies have shown concentration-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva following topical ocular administration.

Pharmacodynamic

Emedastine is a relatively selective H₁-receptor antagonist.

Pharmacokinetics

• Absorption: extremely low systemic exposure
• Half-Life: 3-4 hr
• Metabolism: liver
• Excretion: kidney

Dosage

Allergic Conjunctivitis

Adult

1 gtt in affected eye(s), maximum QID

Pediatric

<3 years old: Safey & efficacy not established

>3 years old: As adults; 1 gtt in affected eye(s), maximum QID

Drug contraindications

Hypersensitivity

Side effects

Sinusitis , Headache , Blurred vision , asthenia , dry eyes , Rhinorrhea , hyperemia , itchy eyes

Interactions

Epinastine

Alerts

Do not wear contact lenses if eyes are red; wait 10 min after emedastine to insert contacts

Points of recommendation

Do not use emedastine to treat contact lens irritation.

Do not wear contact lenses if your eyes are red.

Use care when driving or doing other tasks that call for clear eyesight.

Wash hands before and after use.

Take out contact lenses before using emedastine. Lenses may be put back in 10 minutes after emedastine is given. Do not put contacts back in if your eyes are irritated or infected.

Do not touch the container tip to the eye, lid, or other skin.

Tilt your head back and drop drug into the eye.

After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.

Do not use if solution changes color.

Pregnancy level

B

Related drugs

Olopatadine , Oxymetazoline , Phenylephrine , Naphazoline , Ketotifen , Cromolyn sodium , Azelastine , Epinastine , Antazoline