Drug information of Emedastine


Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis.

Mechanism of effect

Emedastine is a relatively selective, histamine H1 antagonist. In vivo studies have shown concentration-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva following topical ocular administration.


Emedastine is a relatively selective H1-receptor antagonist.


  • Absorption: extremely low systemic exposure
  • Half-Life: 3-4 hr
  • Metabolism: liver
  • Excretion: kidney


Allergic Conjunctivitis


1 gtt in affected eye(s), maximum QID


<3 years old: Safey & efficacy not established

>3 years old: As adults; 1 gtt in affected eye(s), maximum QID

Drug contraindications





Do not wear contact lenses if eyes are red; wait 10 min after emedastine to insert contacts

Points of recommendation

Do not use emedastine to treat contact lens irritation.

Do not wear contact lenses if your eyes are red.

Use care when driving or doing other tasks that call for clear eyesight.

Wash hands before and after use.

Take out contact lenses before using emedastine. Lenses may be put back in 10 minutes after emedastine is given. Do not put contacts back in if your eyes are irritated or infected.

Do not touch the container tip to the eye, lid, or other skin.

Tilt your head back and drop drug into the eye.

After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.

Do not use if solution changes color.

Pregnancy level


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