Drug information of Ribociclib

Ribociclib


Ribociclib is used to treat hormone-related breast cancer in women. Ribociclib is used only if your cancer tests negative for a protein called human epidermal growth factor receptor 2 (HER2).

 Ribociclib is used when the cancer has progressed or has spread to other parts of the body after other treatments.

Ribociclib is given in combination with another cancer medicine such as letrozole (Femara) or fulvestrant (Faslodex).

Mechanism of effect

Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly.

Pharmacokinetics

Not Available

Drug indications

Slowing  the progression of cancer by inhibiting two proteins (cyclin-dependent kinase 4 and 6 (CDK4/6))

Dosage

600 mg orally once a day for 21 consecutive days followed by 7 days off for a complete cycle of 28 days

Drug contraindications

You should not use ribociclib if you are allergic to it, or if you also take tamoxifen.

pregnancy

Side effects

  • Black, tarry, stools
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • chills
  • cough
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • lower back or side pain
  • rapid weight gain
  • sore throat
  • tightness in the chest
  • tingling of the hands or feet
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • diarrhea
  • headache

OxyContin (oxycodone)

Zoladex (goserelin)

Zoloft (sertraline)

Amiodarone

Anagrelide

Bosentan

Chloroquine

Citalopram

Clarithromycin

Alerts

Ribociclib can cause serious side effects on your heart, liver, or lungs. Call your doctor at once if you have chest pain, trouble breathing, cough (with or without mucus), sudden dizziness, right-sided upper stomach pain, loss of appetite, unusual bleeding or bruising, dark urine, or yellowing of your skin or eyes.

Points of recommendation

Tell your doctor if you have ever had:

  • slow heartbeats;
  • heart disease or prior heart attack;
  • long QT syndrome;
  • an electrolyte imbalance (such as low levels of calcium, magnesium, phosphorus, or potassium in your blood);
  • liver disease;
  • kidney disease; or
  • signs of infection (fever, chills).

You may need to have a negative pregnancy test before starting this treatment.

Do not use ribociclib if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using ribociclib and for at least 3 weeks after your last dose.

This medicine may affect fertility (ability to have children) in men. 

You should not breastfeed while using this medicine and for at least 3 weeks after your last dose.

Pregnancy level

You may need to have a negative pregnancy test before starting this treatment

Related drugs

Abemaciclib , Palbociclib


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