Drug information of flurbiprofen

flurbiprofen

Drug group:

Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID). Flurbiprofen works by reducing hormones that cause inflammation and pain in the body.

Pharmacodynamic

Flurbiprofen, a nonsteroidal anti-inflammatory agent (NSAIA) of the propionic acid class, is structually and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen, and has similar pharmacological actions to other prototypica NSAIAs. Flurbiprofen exhibits antiinflammatory, analgesic, and antipyretic activities..

Pharmacokinetics

Absorption

Rapid

Distribution

Vd: 0.12 L/kg

Metabolism

Hepatic via CYP2C9; major metabolite is 4-hydroxy-flurbiprofen (inactive)

Excretion

Urine (<3% as unchanged; ~70% primarily as metabolites)

Time to Peak

~2 hours

Half-Life Elimination

4.7 to 5.7 hours

Protein Binding

>99%, primarily albumin

Drug indications

Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis

Dosage

Usual Adult Dose for Osteoarthritis

200 mg to 300 mg orally per day in 2 to 4 divided doses
Maximum single dose: 100 mg

Usual Adult Dose for Rheumatoid Arthritis

200 mg to 300 mg orally per day in 2 to 4 divided doses
Maximum single dose: 100 mg

Drug contraindications

Hypersensitivity to flurbiprofen or any component of the formulation; history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.

Canadian labeling: Additional contraindications (not in US labeling): Severe uncontrolled heart failure; active gastric/duodenal/peptic ulcer; active GI bleeding; history of recurrent ulceration or active inflammatory GI disease; inflammatory bowel disease; severe hepatic impairment; active hepatic disease; severe renal impairment (CrCl <30 mL/minute or 0.5 mL/second); known hyperkalemia; children and adolescents <18 years of age; breast-feeding; pregnancy (third trimester)

Side effects

  • Abdominal or stomach pain
  • bladder pain
  • bloody or black, tarry stools
  • bloody or cloudy urine
  • constipation
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • rash
  • severe stomach pain
  • swelling
  • vomiting of blood or material that looks like coffee grounds

Alerts

NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

Points of recommendation

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. In particular, tell your doctor or pharmacist if you are taking and of the following medicines:

  • Diuretics (known as water tablets e.g. furosemide, spironolactone)
  • Cardiac glycosides (medicines used for heart conditions, such as digoxin)
  • ACE inhibitors (e.g. captopril) or Angiotensin II antagonists (e.g. losartan). These medicines are used to treat high blood pressure
  • Anti-coagulants (to prevent blood clots e.g. warfarin)
  • Lithium
  • Zidovudine (an anti-viral drug)
  • Methotrexate (used to treat certain cancers)
  • Ciclosporin and tacrolimus (immunosuppressants used to dampen down your immune response)
  • Medicines known as corticosteroids (used in the treatment of inflammatory diseases e.g. prednisone, dexamethasone, hydrocortisone)
  • Anti-depressant medication known as selective serotonin reuptake inhibitors (SSRls) (e.g. fluoxetine and paroxetine)
  • Antibiotics called quinolones (such as ciprofloxacin)
  • Mifepristone (now or in the last 12 days)
  • Any other anti-inflammatory pain killers, including aspirin and the group of drugs known as COX-2 inhibitors e.g. celecoxib, lumiracoxib.

Pregnancy level

US FDA pregnancy category: Not assigned.

Breast feeding warning

US FDA breast feeding category: Not assigned.

Related drugs

Naproxen , Sulindac , Azapropazone


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