Drug information of Bimatoprost


Drug group:

Bimatoprost lowers pressure in the eye by increasing the amount of fluid that drains from the eye

Bimatoprost ophthalmic (for the eyes) is used to treat certain types of glaucoma and other causes of high pressure inside the eye

Bimatoprost ophthalmic may also be used for purposes not listed in this medication guide

Mechanism of effect

As a synthetic analog of prostaglandin with ocular hypotensive activity, bimatoprost decreases intraocular pressure by increasing the outflow of aqueous humor. Bimatoprost may increase the percent and duration of hairs in the growth phase, resulting in eyelash growth


Undergoes oxidation, N-deethylation, and glucuronidation after reaching systemic circulation; forms metabolites
Onset of Action
Reduction of IOP: ~4 hours; Peak effect: Maximum reduction of IOP: ~8 to 12 hours
Time to reach the peak
≤10 minutes
Half life
IV: ≤45 minutes
Urine (67%); feces (25%

Drug indications

Elevated intraocular pressure: Reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension

Hypotrichosis of the eyelashes: Treatment of hypotrichosis of the eyelashes


Usual Adult Dose for Intraocular Hypertension
One drop in the affected eye(s) once a day in the evening
Usual Adult Dose for Glaucoma (Open Angle)
One drop in the affected eye(s) once a day in the evening
Usual Pediatric Dose for Intraocular Hypertension
16 years or older: One drop in the affected eye(s) once a day in the evening
Usual Pediatric Dose for Glaucoma (Open Angle)
16 years or older: One drop in the affected eye(s) once a day in the evening

Drug contraindications

Hypersensitivity to the active component or to any of the ingredients

Safety and efficacy have not been established in patients younger than 16 years

Side effects

Dermatologic: Increased growth in number of eyelashes
Ophthalmic: Conjunctival hyperemia, eye pruritus
 to 10%
Central nervous system: Headache, foreign body sensation of eye
Dermatologic: Erythema of eyelid, hyperpigmentation of eyelashes, local skin hyperpigmentation
Endocrine & metabolic: Hirsutism
Hepatic: Abnormal hepatic function tests
Infection: Infection
Neuromuscular & skeletal: Asthenia
Ophthalmic: Dry eye syndrome, eye irritation, allergic conjunctivitis, asthenopia, blepharitis, burning sensation of eyes, cataract, conjunctival edema, conjunctival hemorrhage, eye discharge, eye pain, iris hyperpigmentation (may be delayed), lacrimation, photophobia, superficial punctate keratitis, visual disturbance
<1%, postmarketing, and/or case reports: Acute bronchospastic disease, bacterial keratitis (caused by inadvertent contamination of multiple-dose ophthalmic solutions), blurred vision, cystoid macular edema, deepening of the eyelid sulcus, dizziness, dyspnea, eyelid edema, hypertension, iritis, local dryness, local hypersensitivity reaction, macular edema, madarosis of eyebrow, nausea, skin rash (including macular and erythematous), trichorrhexis, uveitis

Latanoprost, Latanoprostene Bunod, Nonsteroidal Anti-Inflammatory Agents, Nonsteroidal Anti-Inflammatory Agents (Ophthalmic)


Bimatoprost ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, usually an increase in brown pigment. You may also notice increased growth or thickness of your eyelashes. These changes occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other

Bimatoprost ophthalmic is not approved for use by anyone younger than 16 years old

Do not use this medicine while wearing contact lenses. Bimatoprost ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses

Points of recommendation

You should not use bimatoprost ophthalmic if you are allergic to bimatoprost

To make sure bimatoprost ophthalmic is safe for you, tell your doctor if you have ever had:
swelling or infection in your eye
retinal detachment
eye surgery or injury affecting the lens of your eye

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant

It is not known whether bimatoprost ophthalmic passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding

The usual dose of this medicine is 1 drop into the affected eye every evening. Follow your doctor's dosing instructions very carefully

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine

Tell your doctor right away if you have an eye injury or eye infection, or if you plan to have eye surgery

Reduction of the intraocular pressure starts approximately 4 hours after first administration, with maximum effect reached within approximately 8 to 12 hours

Pregnancy level


There are no adequate and well-controlled studies regarding use in pregnant women to inform a drug-associated risk

Breast feeding warning

Data are not available regarding the presence in human milk, effects on breastfed infants, or effects on milk production

Drug forms

Lumigan, Durysta

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