Drug information of Glutathione

Glutathione

Drug group:

:Use
Male infertility (IM use), atherosclerosis (IV, PO use), cancers, chemotherapy adjunct (IM, IV use), diabetes (IV use), immunostimulant, liver diseases, lung diseases (inhaled use), memory loss, Parkinson's disease (IV, PO use)

Glutathione

Mechanism of effect

It is a powerful antioxidant, co-factor in Phase I hepatic detoxification, involved in synthesis of DNA & proteins, amino acid transport, enzyme activation, immune system function
It is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides

Pharmacodynamic

Not Available

Pharmacokinetics

:Absorption
Research suggests that glutathione is not orally bioactive, and that very little
of oral glutathione tablets or capsules is actually absorbed by the body

:Volume of distribution
Not Available

:Metabolism
Not Available

:Route of elimination
Not Available

:Half-life
Not Available

:Clearance
Not Available

Dosage

Chemotherapy adjunct
600mg/day IM days 2-5 of chemotherapy
1.5g/m² IV before chemotherapy

Male Infertility
600mg IM QOD x 2 months

Oral
250mg PO QD
dosage range: 50-600mg/day

Inhaled
600mg NEB BID

Points of recommendation

:Probable adverse reactions
allergic reaction, like rash, hives, itching, red, swollen, blistered, or peeling skin with or without fever, wheezing, tightness in the chest or throat, trouble breathing, swallowing, or talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat, dizziness or passing out

:Contraindications
Asthma (inhaled use)

:Drug or Food Interactions
Not Available

Pregnancy level

Avoid use

Breast feeding warning

Avoid use

Related drugs

Acethyl cysteine


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