Drug information of Mitiglinide

Mitiglinide

Drug group: blood sugar

Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.

Mitiglinide

Mechanism of effect

Mitiglinide is thought to stimulate insulin secretion by binding to and blocking ATP-sensitive K(+) (K(ATP)) channels (Kir6.2/SUR1 complex, KATP channels) in pancreatic beta-cells. Closure of potassium channels causes depolarization which stimulates calcium influx through voltage-gated calcium channels. High intracellular calcium subsequently triggers the exocytosis of insulin granules.

Pharmacodynamic

Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs. It is approved for use in Japan but has not yet gained FDA approval.

Pharmacokinetics

Not available

Drug indications

diabetes mellitus type2

For the treatment of type 2 diabetes.

Dosage

adults 1 tablet tid
Adult 1 tab tid.
More: https://www.ndrugs.com/?s=mitiglinide

Drug contraindications

severe ketosis, diabetic coma or precoma, type 1 DM, severe infections before or after surgery or serious trauma, pregnancy
Severe ketosis, diabetic coma or precoma, type I DM, severe infections before or after surgery or serious trauma. Pregnancy.
More: https://www.ndrugs.com/?s=mitiglinide#doctor_contraindications
Severe ketosis, diabetic coma or precoma, type I DM, severe infections before or after surgery or serious trauma. Pregnancy.
More: https://www.ndrugs.com/?s=mitiglinide#doctor_contraindications
Severe ketosis, diabetic coma or precoma, type I DM, severe infections before or after surgery or serious trauma. Pregnancy.
More: https://www.ndrugs.com/?s=mitiglinide#doctor_contraindications

Side effects

hypoglysemic symptoms, abdominal distension, constipation, diarrhea, headache, laboratory abnormalities, MI, hepatic dysfunction

hyHypoglycemic symptoms, abdominal distension, constipation, diarrhea, headache, laboratory abnormalities, MI, hepatic dysfunction.
More: https://www.ndrugs.com/?s=mitiglinide#doctor_side%20effects

Interactions

chlorpropamide , Epinephrine , Tetracycline , Phenytoin , Nicotinic acid , Clofibrate , Pioglitazone , Pyrazinamide
biguanides, pioglitazone HCl, salicylates, clofibrate, sulfanilamide, MAOIs; anabolic, adrenocortical, ovarian and thyroid hormone; tetracyclines, epinephrine, ncotinic acid, INH, pyrazinamide, phenotiazines, duretics, phenytoin.

Pregnancy level

contraindicated


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