Drug information of Meticillin


Drug group:

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Methicillin, also called meticillin, antibiotic formerly used in the treatment of bacterial infections caused by organisms of the genus Staphylococcus. Methicillin is a semisynthetic derivative of penicillin. 

Mechanism of effect

Similar to other beta-lactam antimicrobials, meticillin blocks synthesis of the bacterial cell wall. Meticillin stops cross-linkage between the peptidoglycan polymer chains, which make up a large portion of gram-positive bacterial cell walls. It does this by binding to and competitively inhibiting the transpeptidase enzyme used by bacteria to cross-link the peptide (D-alanyl-alanine) used in peptidogylcan synthesis.


Meticillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class. It is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphylococcus aureus strains resistant to all penicillins.

Drug indications

Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.

Side effects

  • Side effects associated with its use included diarrheaand allergic reactions, such as skin rash and anaphylaxis. Some patients experienced severe hemorrhagic cystitis, characterized by inflammation and hemorrhaging of the bladder.


Sarecycline , Omadacycline


Not absorbed following oral administration.
Volume of distribution
Not Available
Protein binding
Not Available
Hepatic (20-40%).
Route of elimination
Not Available
25-60 minutes

Ask a Pharmacist

User's questions
    No comments yet.