Mechanism of effect
Antigenic capsular polysaccharides induce Ab production.
Pharmacokinetics
The onset of protection from disease is relatively slow, but duration is long lasting (years)
Dosage
Adult
H. influenzae Type B Immunization
Asplenia
- One dose of HIB vaccine should be administered if HIB vaccine not previously received
- HIB vaccination should be given ≥14 days before splenectomy
Complement deficiency
- One dose of HIB vaccine should be administered if HIB vaccine not previously received
Post-HSCT Recipients
- Recipients of a hematopoietic stem cell transplant (HSCT) should be vaccinated with a 3-dose regimen 6 to 12 months after a successful transplant, regardless of vaccination history
- At least 4 weeks should separate doses
Pediatric
H. influenzae Type B Immunization
IM injection indicated for routine immunization in children aged 2 months to 15 months and up to 5 years for catch up vaccination
Primary series (6 weeks to 12 months): 2 or 3 doses
Booster: 3rd or 4th dose between 12-15 months
Interactions
Azathioprine , Everolimus , Infliximab , Budesonide , Tacrolimus , Deflazacort , Alefacept , Anakinra , Daclizumab , Adalimumab , Prednisolone , Golimumab , Tocilizumab , Canakinumab , Basiliximab , Methylprednisolone , Hydroxychloroquine , Hydrocortisone , mercaptopurine , prednisone , cortisone , Dexamethasone , Sirolimus , Cyclosporine , Fludrocortisone , Glatiramer acetate , Methotrexate , secukinumabAlerts
If Guillain-Barré syndrome has occurred within 6 wk of receipt of a prior vaccine containing tetanus toxoid, the decision to give any tetanus toxoid-containing vaccine should be based on careful consideration of the potential benefits and possible risks
Syncope can occur in association with administration of injectables and may be accompanied by transient neurological signs (eg, visual disturbance, paresthesia, tonic-clonic limb movements): procedures should be in place to avoid falling injury and to restore cerebral perfusion following syncope
Apnea reported following IM vaccination in some infants born prematurely; decisions about when to administer an IM vaccine to infants born prematurely should be based on consideration of the individual infant’s medical status, and the potential benefits and possible risks of vaccination
Prior to administration, the healthcare provider should review the patient's immunization history for possible vaccine hypersensitivity; epinephrine and other appropriate agents used for the control of immediate allergic reactions must be immediately available should an acute anaphylactic reaction occur
Safety and effectiveness in immunosuppressed children have not been evaluated; if administered to immunosuppressed children, the expected immune response may not be obtained
Points of recommendation
Your doctor may recommend reducing fever and pain by giving the child an aspirin-free pain reliever such as acetaminophen or ibuprofen when the shot is given and for the next 24 hours.
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