Mechanism of effect
Amisulpride binds selectively to dopamine D(2) and D(3) receptors in the limbic system. Low doses of amisulpride preferentially block presynaptic D(2)/D(3)-dopamine autoreceptors, thereby enhancing dopaminergic transmission, whereas higher doses block postsynaptic receptors, thus inhibiting dopaminergic hyperactivity. It may also have 5-ht7 antagonistic effect, useful in depression treatment.
Pharmacodynamic
Not Available
Pharmacokinetics
Absorption: Bioavailability is 48% following oral administration.
Protein binding: Low (17%)
Half life: Approximately 12 hours
Drug indications
depressionDosage
Adults and children over the age of 18 years old
The usual dose of Amisulpride Tablets is between 50 mg and 800mg per day. The dose may be increased up to 1200mg per day. If you are taking 400 mg or less of amisulpride,you should take this once a day. If you are taking more than 400 mg amisulpride a day you should divide the dose into two -take half in the morning and half in the evening.
Side effects
Anxiety , Insomnia , dry mouth , hypotension , impotence , malaise , Tremor , Weight increase , RestlessnessInteractions
Sodium Oxybate , Dolasetron , Procainamide , Dofetilide , Promazine , Chlorthalidone , Arsenic trioxide , Amphotericin B , Amiodarone , Erythromycin , Imipramine , Bromocriptine , Pimozide , Guanfacine , Halofantrine , Vincamine , Sultopride , Bepridil , Pentamidine , lithium , Quinidine , Droperidol , sparfloxacin , Mefloquine , Cisapride , Methadone , Haloperidol , Verapamil , Clonidine , Levodopa , Tetracosactid , Thioridazine , Disopyramide , Diltiazem , Ropinirole , Sotalol , Rotigotine , lenvatinib , Pitolisant , Cariprazine , gilteritinib , glasdegib , Romidepsin , bedaquiline , DasatinibAlerts
have kidney problems
-have Parkinson's disease(tremor, stiffness and shuffling)
-have a history of epileptic seizures(fits)
-have a heart problem, or a family history of heart disease
-have a slow heart beat
-have low potassium levels in your blood (hypokalaemia)
-have diabetes or you are at a higher risk of having diabetes
-or someone else in your family has a history of blood clots, as medicines like these have been associated with formation of blood clots
-have abnormally high body temperature
-have had a stroke before
-are elderly and suffering from impaired brain function(Dementia)
are elderly.
-have lapp lactose deficiency (you are unable to digest milk or milk product)
-elderly suffering from renal failure
-you have frequent infections such as fever, severe chills, sore throat or mouth ulcers. These could be signs of a blood problem called leukopenia
During your treatment with Amisulpride blood test and ECG monitoring may be performed.
Points of recommendation
Some types of meal may affect how quickly Amisulpride Tablets start to work. If possible, it is best to take Amisulpride tablets before a meal and at about the same time(s) each day.
-You should not drink alcohol while you are taking Amisulpride Tablets as the effects of alcohol may be increased
Do not take Amisulpride Tablets if you are pregnant, planning to become pregnant, or are breast-feeding.
Amisulpride Tablets may affect your ability to drive a car or use machines. Do not drive or use machines until you know how Amisulpride Tablets affect you.
Always swallow your tablets with plenty of water before a meal and about the same time each day
If you forget to take a dose, take it as soon as you remember, unless it is nearly time for your next dose. Do not take a double dose to make up for the one you have missed.
Do not stop taking Amisulpride Tablets just because you feel better. You should only stop taking your tablets if advised by your doctor. Stopping Amisulpride abruptly, may cause withdrawal effects such as feeling sick, vomiting, sweating, sleeplessness, extreme restlessness, muscle stiffness abnormal movements or your original condition may come back. Always follow your doctor‟s instructions carefully.
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