Drug information of Azapropazone


Drug group:

Azapropazone is one of a group of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs), which reduce swelling and pain in joints and muscles.

Mechanism of effect

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.


Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma.


Not available

Drug indications

artirit rhomatoid


Adults under 60 years old with good kidney function

For the treatment of rheumatoid arthritis and ankylosing spondylitis 1200 mg daily in divided doses.

For the treatment of acute gout, 1800 mg per day in divided doses. By the fourth day, when the pain and swelling should have improved, it is usual to reduce the dose to 1200 mg per day in divided doses. If the conditions does not significantly improve consult your doctor. Drink plenty of liquids when taking Azapropazone for acute gout.


You have any problems with your stomach, heart or liver.

  You have any problems with your kidneys or are taking a diuretic (water tablets).

  You suffer from fluid retention or high blood pressure.

  You suffer from bronchial asthma or an allergy which sometimes causes you difficulty in breathing.

  You are pregnant, trying to become pregnant or are breast feeding.

 You are diabetic.

  You are taking any other medicine including lithium, digoxin, cimetidine or corticosteroids.

You have had problems in the past while taking a non-steroidal anti-inflammatory drug (eg aspirin).

Points of recommendation

Drink plenty of liquids when taking Azapropazone for acute gout.

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