Drug information of Zinc pyrithione

Zinc pyrithione

Drug group:

Pyrithione zincis a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. Due to its dynamic fungistatic and bacteriostatic properties, pyrithione zinc is used to treat dandruff and seborrheic dermatitis.

Zinc pyrithione

Mechanism of effect

It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth. Due to low solubility, pyrithione zinc released from the topical formulations is deposited and retained relatively well onto the target skin surfaces.

Drug indications

It is used to control seborrheic dermatitis , It is used to treat skin irritation and dandruff

Dosage

Adult

Seborrhea

Shampoo: Apply to wet hair/scalp, lather, then rinse well; may follow with conditioner

Pediatric

Safety and efficacy not established

Drug contraindications

Hypersensitivity

Side effects

Stinging/burning of scalp , Desquamation

Alerts

Topical use only

Avoid contact with eyes

Points of recommendation

  • If pyrithione zinc shampoo gets in the eyes, rinse with cool water.
  • Do not take pyrithione zinc shampoo by mouth. Use on your scalp and hair only. Keep out of your mouth, nose, ears, and eyes (may burn).
  • Shake well before use.
  • Wet hair and scalp.
  • Work into a lather and rinse.

Pregnancy level

C

Related drugs

vitamin E+Selenium , Ketoconazole , Salicylic acid , Selenium Sulfide


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