Drug information of Zinc pyrithione

Zinc pyrithione

Drug group:

Pyrithione zincis a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers. Due to its dynamic fungistatic and bacteriostatic properties, pyrithione zinc is used to treat dandruff and seborrheic dermatitis.

Mechanism of effect

It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth. Due to low solubility, pyrithione zinc released from the topical formulations is deposited and retained relatively well onto the target skin surfaces.




Shampoo: Apply to wet hair/scalp, lather, then rinse well; may follow with conditioner


Safety and efficacy not established

Drug contraindications



Topical use only

Avoid contact with eyes

Points of recommendation

  • If pyrithione zinc shampoo gets in the eyes, rinse with cool water.
  • Do not take pyrithione zinc shampoo by mouth. Use on your scalp and hair only. Keep out of your mouth, nose, ears, and eyes (may burn).
  • Shake well before use.
  • Wet hair and scalp.
  • Work into a lather and rinse.

Pregnancy level


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