Drug information of Lymecycline


Drug group: Tetracyclines

A tetracycline with a 7-chloro substitution.

Mechanism of effect

Lymecycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Lymecycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Cells become resistant to lymecycline by at least two mechanisms: efflux and ribosomal protection.

In efflux, a resistance gene encodes a membrane protein that actively pumps lymecycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents lymecycline from acting on the ribosome.


Lymecycline is a tetracycline broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall, making use of the same fast and efficient mechanism by which carbohydrates are absorbed


Absorption: Absorption is fast and efficient. Bioavailability is 100% following oral administration.


Adults and children over 12 years
Moderate to severe acne

The normal dose is one Lymecycline capsule once a day, preferably in the morning.

How long you will have to take Lymecycline for will depend on how quickly your condition improves. For
acne, this will normally be at least 8 to 12 weeks. Your physician may decide to continue with treatment for a maximum of 6 months.
Children under 12 years
Lymecycline is not recommended for use in children under 12 years of age as it can cause permanentdiscolouration of tooth enamel and affect bone development.


if you have had liver problems
if you have had kidney problems
if you suffer from systemic lupus erythematosus (an allergic condition that causes joint pain, skin
rashes or fever)
if you suffer from Myasthenia Gravis (a disease that weakens the muscles) .

Points of recommendation

You should avoid direct exposure to sunlight or artificial sunlight from sunbeds. If you experience skin
discomfort then stop taking this medicine and seek advice from your doctor.

Lymecycline should always be taken with a glass of water.

If you forget to take a dose, simply take it when you remember and carry on as before unless it is time for the next dose. Do not take a double dose to make up for a forgotten dose. You should never take more capsules than your doctor recommends.
If you stop taking Lymecycline Acne responds slowly to antibiotics. It is important that you take all the Lymecycline that your doctor has prescribed for you. If you stop taking Lymecycline too soon, your acne or infection could get worse or come back.

Lymecyclinecapsules should always be taken with a glass of water, whilst in an upright position. They should also be taken with a light meal without dairy products.

Pregnancy level


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