Drug information of Parecoxib

Mechanism of effect

It is one of a family of medicines called COX-2 inhibitors (this is short for cyclo-oxygenase-2 inhibitors). Pain and swelling are sometimes caused by substances in the body called prostaglandins. Parecoxib works by lowering the amount of these prostaglandins.

Pharmacodynamic

Not Available

Pharmacokinetics

Protein binding: 98%

Metabolism: Hepatic. Metabolized primarily via CYP3A4 and 2C9 to valdecoxib and propionic acid.

Half life: 22 minutes

Drug indications

Pain

Dosage

>18 years old

The usual dose to start with is 40 mg.You may be given another dose –either 20 mg or 40 mg –6 to 12 hours after the first one.You will not be given more than 80 mg in 24 hours.

Drug contraindications

cardiovascular conditions , Breast feeding , Crohn's disease , cardiac failure , gastrointestinal hemorrhage , Hypersensitivity to this drug , ulcerative colitis , hypersensitivity to salicylates , allergic to this drug and any ingredients , hypersensitivity to sulfonamides

Side effects

nausea , vomiting , vertigo , Hypertension , hypotension , dyspepsia , Peripheral edema , Kidney function abnormal , Hypokalemia , flatulence , oliguria , tiredness , Restlessness , shortness of breath , stomach pain

Interactions

Tanacetum parthenium , Feverfew , Drospirenone , Doxazosin , Felbamate , Ginkgo biloba , Tacrolimus , Diazepam , Cyclosporine , Fluconazole , Phenytoin , Methotrexate , Warfarin , Carbamazepine , Aspirin , lithium , Efavirenz , Bromfenac , Cordyceps , Netonal , Aminohippurate Sodium

Alerts

If you have previously had an ulcer, bleeding or perforation of the gastrointestinal tract§If you are taking acetylsalicylic acid (aspirin) or other NSAIDs(e.g. ibuprofen)§If you smoke or drink alcohol§If you have diabetes§If you have angina, blood clots, high blood pressure or raised cholesterol§If you are taking anti-platelet therapies(e.g. acetylsalicylic acid)§If you have fluid retention (oedema)§If you have liver or kidney disease.§If you are dehydrated–this may happen if you have had diarrhoea or have been vomiting (being sick) or unable to drink fluids§If you have an infection as it may hide a fever (which is a sign of infection)§If you use medicines to reduce blood clotting(e.g. warfarin/warfarin like anticoagulants or novel oral anti-clotting medicines, e.g. apixaban, dabigatran, and rivaroxaban)§If you use medicines called corticosteroids (e.g. prednisone)§If you use a class of medicines used to treat depression called selective serotonin re-uptake inhibitors(e.g. sertraline)Parecoxib can lead to an increase in blood pressure or worsening of existing high blood pressure which may result in an increase in side-effects associated with heart conditions. Your doctor may want to monitor your blood pressure during treatment with Parecoxib.

Points of recommendation

If the injection makes you feel dizzy or tired, do not drive or use machines until you feel better again.

Related drugs

Celecoxib , Valdecoxib , Rofecoxib