Drug information of Parecoxib
Parecoxib is used for the short-term treatment of pain in adults after an operation.It is one of a family of medicines called COX-2 inhibitors (this is short for cyclo-oxygenase-2 inhibitors). Pain and swelling are sometimes caused by substances in the body called prostaglandins. Parecoxib works by lowering the amount of these prostaglandins.
Mechanism of effect
It is one of a family of medicines called COX-2 inhibitors (this is short for cyclo-oxygenase-2 inhibitors). Pain and swelling are sometimes caused by substances in the body called prostaglandins. Parecoxib works by lowering the amount of these prostaglandins.
Protein binding: 98%
Metabolism: Hepatic. Metabolized primarily via CYP3A4 and 2C9 to valdecoxib and propionic acid.
Half life: 22 minutes
>18 years old
The usual dose to start with is 40 mg.You may be given another dose –either 20 mg or 40 mg –6 to 12 hours after the first one.You will not be given more than 80 mg in 24 hours.
Drug contraindicationscardiovascular conditions , Breast feeding , Crohn's disease , cardiac failure , gastrointestinal hemorrhage , Hypersensitivity to this drug , ulcerative colitis , hypersensitivity to salicylates , allergic to this drug and any ingredients , hypersensitivity to sulfonamides
Side effectsnausea , vomiting , vertigo , Hypertension , hypotension , dyspepsia , Peripheral edema , Kidney function abnormal , Hypokalemia , flatulence , oliguria , tiredness , Restlessness , shortness of breath , stomach pain
InteractionsTanacetum parthenium , Feverfew , Drospirenone , Doxazosin , Felbamate , Ginkgo biloba , Tacrolimus , Diazepam , Cyclosporine , Fluconazole , Phenytoin , Methotrexate , Warfarin , Carbamazepine , Aspirin , lithium , Efavirenz , Bromfenac , Cordyceps , Netonal , Aminohippurate Sodium
If you have previously had an ulcer, bleeding or perforation of the gastrointestinal tract§If you are taking acetylsalicylic acid (aspirin) or other NSAIDs(e.g. ibuprofen)§If you smoke or drink alcohol§If you have diabetes§If you have angina, blood clots, high blood pressure or raised cholesterol§If you are taking anti-platelet therapies(e.g. acetylsalicylic acid)§If you have fluid retention (oedema)§If you have liver or kidney disease.§If you are dehydrated–this may happen if you have had diarrhoea or have been vomiting (being sick) or unable to drink fluids§If you have an infection as it may hide a fever (which is a sign of infection)§If you use medicines to reduce blood clotting(e.g. warfarin/warfarin like anticoagulants or novel oral anti-clotting medicines, e.g. apixaban, dabigatran, and rivaroxaban)§If you use medicines called corticosteroids (e.g. prednisone)§If you use a class of medicines used to treat depression called selective serotonin re-uptake inhibitors(e.g. sertraline)Parecoxib can lead to an increase in blood pressure or worsening of existing high blood pressure which may result in an increase in side-effects associated with heart conditions. Your doctor may want to monitor your blood pressure during treatment with Parecoxib.
Points of recommendation
If the injection makes you feel dizzy or tired, do not drive or use machines until you feel better again.