Drug information of fenoprofen

fenoprofen

Drug group:

Mechanism of effect

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.

 Other proposed mechanisms not fully elucidated (and possibly contributing to the anti-inflammatory effect to varying degrees), include inhibiting chemotaxis, altering lymphocyte activity, inhibiting neutrophil aggregation/activation, and decreasing proinflammatory cytokine levels.

Pharmacokinetics

Absorption

Rapid

Metabolism

Extensively hepatic

Onset of Action

A few days; full benefit: up to 2 to 3 weeks

Time to reach the peak

Serum: ∼2 hours

Half life

~3 hours

Excretion

Urine (~90% as metabolites)

Drug indications

1-Osteoarthritis: Relief of the signs and symptoms of osteoarthritis.

2-Pain: Relief of mild to moderate pain in adults.

3-Rheumatoid arthritis (RA): Relief of the signs and symptoms of RA.

Dosage

Usual Adult Dose for Osteoarthritis

400 mg to 600 mg orally 3 or 4 times a day

-Maximum dose: 3200 mg/day

Usual Adult Dose for Rheumatoid Arthritis

400 mg to 600 mg orally 3 or 4 times a day

-Maximum dose: 3200 mg/day

Usual Adult Dose for Pain

200 mg orally every 4 to 6 hours as needed

Drug contraindications

Hypersensitivity to fenoprofen (eg, anaphylactic reactions, serious skin reactions) or any component of the formulation; history of asthma, urticaria, or allergic-type reaction to aspirin or other NSAIDs; in the setting of coronary artery bypass graft (CABG) surgery; severe renal impairment (ProFeno only).

Side effects

1% to 10%:

Cardiovascular: Peripheral edema, palpitations

Central nervous system: Drowsiness, headache, dizziness, nervousness, fatigue, confusion

Dermatologic: Diaphoresis, pruritus, skin rash

Gastrointestinal: Dyspepsia, nausea, constipation, vomiting, abdominal pain

Neuromuscular & skeletal: Weakness (5%), tremor (2%)

Ophthalmic: Blurred vision

Otic: Tinnitus, auditory impairment

Respiratory: Dyspnea, nasopharyngitis

Dosage

Usual Adult Dose for Osteoarthritis

400 mg to 600 mg orally 3 or 4 times a day

-Maximum dose: 3200 mg/day

Usual Adult Dose for Rheumatoid Arthritis

400 mg to 600 mg orally 3 or 4 times a day

-Maximum dose: 3200 mg/day

Usual Adult Dose for Pain

200 mg orally every 4 to 6 hours as needed

5-Aminosalicylic Acid Derivatives, Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.), Alcohol (Ethyl), Aminoglycosides, Aminolevulinic Acid (Systemic), Angiotensin II Receptor Blockers, Angiotensin-Converting Enzyme Inhibitors, Anticoagulants, Beta-Blockers, Bile Acid Sequestrants, Bisphosphonate Derivatives, Cephalothin,

Collagenase (Systemic), Corticosteroids Dexibuprofen, Dexketoprofen, Fat Emulsion (Fish Oil Based), Felbinac, Floctafenine,Herbs (Anticoagulant/Antiplatelet Properties) (eg, Alfalfa, Anise, Bilberry), Limaprost, Loop Diuretics,Mifamurtide, Morniflumate, Multivitamins/Fluoride (with ADE), Multivitamins/Minerals (with ADEK, Folate, Iron), Multivitamins/Minerals (with AE, No Iron), Naftazone, Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective), Obinutuzumab,Pelubiprofen, Pentosan Polysulfate Sodium, Potassium-Sparing Diuretics, Prostacyclin Analogues, Prostaglandins (Ophthalmic), Quinolones, Salicylates, Selective Serotonin Reuptake Inhibitors,Serotonin/Norepinephrine Reuptake Inhibitors, Sincalide, Talniflumate,  Tenoxicam, Thiazide and Thiazide-Like Diuretics,Thrombolytic Agents, Tipranavir, Tolperisone, Tricyclic Antidepressants (Tertiary Amine), Vitamin K Antagonists (eg, warfarin),Zaltoprofen

Alerts

1-This medicine may raise the risk of heart and blood vessel problems like heart attack and stroke. These effects can be deadly. The risk may be greater if you have heart disease or risks for heart disease. However, it can also be raised even if you do not have heart disease or risks for heart disease. The risk can happen within the first weeks of using fenoprofen and may be greater with higher doses or long-term use. Do not use fenoprofen right before or after bypass heart surgery.

2-This medicine may raise the chance of severe and sometimes deadly stomach or bowel problems like ulcers or bleeding. The risk is greater in older people, and in people who have had stomach or bowel ulcers or bleeding before. These problems may occur without warning signs.

3-A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Points of recommendation

1-Avoid driving and doing other tasks or actions that call for you to be alert until you see how fenoprofen affects you.

2-Have your blood work checked if you are on fenoprofen for a long time. Talk with your doctor.

3-High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.

4-Talk with your doctor before you drink alcohol.

5-If you have asthma, talk with your doctor. You may be more sensitive to fenoprofen.

6-You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.

7-The chance of heart failure is raised with the use of drugs like this one. In people who already have heart failure, the chance of heart attack, having to go to the hospital for heart failure, and death is raised. Talk with the doctor.

8-Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

9-NSAIDs like fenoprofen may affect egg release (ovulation) in women. This may cause you to not be able to get pregnant. This goes back to normal when fenoprofen is stopped. Talk with your doctor.

Storage

Store at 20°C to 25°C (67°F to 77°F) excursions permitted between 15°C to 30°C (59°F to 86°F). Protect from light.

Pregnancy level

C

avoid during third trimester, may cause premature closure of the ductus arteriosus.

Breast feeding warning

excretion in milk unknown/not recommended.

Drug forms

Fenortho, Nalfon, ProFeno

Ask a Pharmacist


User's questions
    No comments yet.