Drug information of quinapril
Mechanism of effect
Angiotensin II constricts coronary blood vessels and is positively inotropic, which under normal circumstances, would increase vascular resistance and oxygen consumption.
This action can eventually lead to myocyte hypertrophy and vascular smooth muscle cell proliferation. Angiotensin II also stimulates production of plasminogen activator inhibitor-1 (PAI-1), increasing the risk of thrombosis. Quinaprilat prevents the conversion of angiotensin I to angiotensin II by inhibition of angiotensin converting enzyme, and also reduces the breakdown of bradykinin. Reduced levels of angiotensin II lead to lower levels of PAI-1, reducing the risk of thrombosis, especially after a myocardial infarction.
Drug indicationsCongestive heart failure
Quinapril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used to treat heart failure. Quinapril belongs to a class of drugs known as ACE inhibitors.
Usual Adult Dose for Hypertension
Initial dose: 10 or 20 mg orally once a day in patients not on diuretics
Maintenance dose: 20 to 80 mg orally per day, administered as a single dose or in two equally divided doses
Usual Adult Dose for Congestive Heart Failure
Initial dose: 5 mg orally twice a day
Maintenance dose: 20 to 40 mg orally per day administered in two equally divided doses
Usual Geriatric Dose for Congestive Heart Failure
10 mg orally once a day
Usual Geriatric Dose for Hypertension
10 mg orally once a day
Drug contraindicationspregnancy , Angioedema , Hypersensitivity
Side effectsstomach disorders , Diarrhea , Headache , nausea , vomiting , vertigo , tiredness , shortness of breath
- Nauseaand/or vomiting
- Low blood pressure(hypotension)
- Shortness of breath
- Skinitching or rash
- Back pain
InteractionsAmlodipine/Atorvastatine , Drospirenone , Iron sucrose , potassium citrate , Doxazosin , Triamterene , Dalteparin , Misoprostol , Canagliflozin , Telmisartan , Sacubitril and valsartan , Celecoxib , Lymecycline , Sulindac , Azilsartan , Candesartan , Irbesartan , Olmesartan , Aliskiren , Treprostinil , atovaquone/proguanil , Sulfamethoxazole , Iron Dextran Complex , Remdesivir , Bacampicillin , Nesiritide , Angiotensin II
Points of recommendation
Before taking quinapril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, liver disease.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your doctor. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.
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