Drug information of Trientine
Triethylenetatramine (TETA) is a highly selective divalent Cu(II) chelator that revereses copper overload in tissues. Its salt form, trientine was introduced in 1969 as an alternative to D-penicillamine. It consists of a polyamine-like structure different from D-penicillamine, as it lack sulfhydryl groups.
Mechanism of effect
Oral chelating agent used to induce adequate cupriuresis
Excretion: Urine (9%)
Drug indicationsWilson's disease
For patients intolerant of penicillamine
750-1250 mg/day PO divided q6-12hr; not to exceed 2 g/day
- 500-750 mg/day PO divided q6-12hr; not to exceed 1.5 g/day
- For patients intolerant of penicillamine: 750-1250 mg/day PO divided q6-12hr; not to exceed 2 g/day
Hypersensitivity to product or components
Side effectsHeartburn , anorexia , aplastic anemia, , Abdominal pain , Rash , Systemic Lupus Erythematosus , Myasthenia gravis
Iron deficiency, Aphthoid ulcer, Sideroblastic anemia, Lupus like eruption
Not indicated for cystinuria, RA or biliary cirrhosis
May cause iron deficiency anemia
Hepatic iron oveload may result from copper deficiency induced by therapy
Monitor urinary copper and for signs of hypersensitivity (eg, elevated body temperature)
Points of recommendation
- Tell all of your health care providers that you take trientine. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have your urine checked as you have been told by your doctor.
- During the first month you take trientine, take your temperature every night. Call your doctor if you have a fever or skin irritation.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using trientine while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- Take on an empty stomach. Take at least 1 hour before or 2 hours after meals. Take at least 1 hour before or after any other drug, food, or milk.
- Do not take iron products within 2 hours before or 2 hours after taking trientine.
- If you take other products with minerals in them (like aluminum, calcium, magnesium, or zinc), talk with your doctor. You may need to avoid these products while taking trientine.
- Swallow whole. Do not chew, open, or crush.
- Take with a full glass of water.
- If the capsule is opened or broken, do not touch the contents. If the contents are touched or they get in the eyes, wash hands or eyes right away.
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.