Drug information of Dexfenfluramine


Drug group:

Dexfenfluramine is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.

Mechanism of effect

Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.


Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Dexfenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes.


Absorption: Well-absorbed from the gastrointestinal tract. 

Protein binding: 36%


Half life: 17-20 hours

Drug indications

weight decrease , Obesity management


Usual Adult Dose for Weight Loss

15 mg orally twice a day, with meals.
Doses above 30 mg/day are not recommended.


Not available

Points of recommendation

Not available

Pregnancy level

Group c - Not adequate studies in pregnant women

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