Drug information of Xylometazoline


Xylometazoline

Drug group: Decongestants

A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways.

Mechanism of effect

Xylometazoline is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activates the adrenal system to yield systemic vasoconstrction. In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and consequently decreased nasal congestion.

Pharmacodynamic

Xylometazoline is a direct acting sympathomimetic adrenergic alpha-agonist used to induce systemic vasoconstriction, thereby decreasing nasal congestion.

Pharmacokinetics

Onset: 5-10 min

Duration: 5-6 hr

Drug indications

nasal stuffiness

Dosage

Adult

Nasal Congestion

<12 years: Not recommended

>12 years: 0.05% Spray (2-3 gtt/sprays) per nostril q8-10hr, no more than 3 doses/day

Pediatric

Nasal Congestion

0.05% Spray (2-12 years old): 2-3 gtt per nostril q8-10hours; not to exceed 3 doses/24 hours

Drug contraindications

Concomitant with MAOIs

Side effects

Anxiety , dizziness , Tremor , stinging

Alerts

None

Points of recommendation

  • Tell all of your health care providers that you take xylometazoline. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not use for more than 3 days. Using xylometazoline too often or for longer than you have been told may cause nose stuffiness to happen again or get worse.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using xylometazoline while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
  • Do not take xylometazoline by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn).
  • Blow your nose before use.
  • When using, tilt your head forward a little.
  • While breathing in through the nose, press down once to release spray.
  • If you use xylometazoline on a regular basis, use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses at the same time or extra doses.
  • Many times xylometazoline is used on an as needed basis. Do not use more often than told by the doctor.

Pregnancy level

Group c - Not adequate studies in pregnant women


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