Drug information of Xylometazoline
A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways.
Mechanism of effect
Xylometazoline is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activates the adrenal system to yield systemic vasoconstrction. In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and consequently decreased nasal congestion.
Xylometazoline is a direct acting sympathomimetic adrenergic alpha-agonist used to induce systemic vasoconstriction, thereby decreasing nasal congestion.
Onset: 5-10 min
Duration: 5-6 hr
Drug indicationsnasal stuffiness
<12 years: Not recommended
>12 years: 0.05% Spray (2-3 gtt/sprays) per nostril q8-10hr, no more than 3 doses/day
0.05% Spray (2-12 years old): 2-3 gtt per nostril q8-10hours; not to exceed 3 doses/24 hours
Drug contraindicationsConcomitant with MAOIs
InteractionsDoxapram , Amitriptyline , Isoflurane , Imipramine , Trazodone , Tranylcypromine , Trimipramine , Methoxyflurane , Ergoloid Mesylate , lofepramine , Linezolid , Phenelzine , Desflurane , Amoxapine , isocarboxazid , protriptyline , Methylergonovin , Nortriptyline , Cabergoline , Clomipramine , Yohimbine , ergotamine , Desipramine , Doxepin , Dihydroergotamine , Selegiline , Sevoflurane , Maprotiline
Points of recommendation
- Tell all of your health care providers that you take xylometazoline. This includes your doctors, nurses, pharmacists, and dentists.
- Do not use for more than 3 days. Using xylometazoline too often or for longer than you have been told may cause nose stuffiness to happen again or get worse.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using xylometazoline while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- Do not take xylometazoline by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn).
- Blow your nose before use.
- When using, tilt your head forward a little.
- While breathing in through the nose, press down once to release spray.
- If you use xylometazoline on a regular basis, use a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not use 2 doses at the same time or extra doses.
- Many times xylometazoline is used on an as needed basis. Do not use more often than told by the doctor.