Drug information of Gatifloxacin

Gatifloxacin

Drug group:

Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family.

Mechanism of effect

The bactericidal action of Gatifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

Pharmacodynamic

Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Gatifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Pharmacokinetics

Absorption: undetectable systemic

Dosage

Adult and pediatric

<1 year: Safety and efficacy not established

Bacterial Conjunctivitis

Drop 0.3%

  • Days 1-2: Instill 1 gtt to affected eye(s) q2hr while awake, up to 8 xday
  • Days 3-7: Instill 1 gtt to affected eye(s) up to QID

Drop 0.5%

  • Day 1: Instill 1 gtt to affected eye(s) q2hr while awake, up to 8 xday
  • Days 2-7: Instill 1 gtt BID-QID on Days 2-7

Alerts

Prolonged use may result in overgrowth of nonsusceptible organisms (incl fungi)

Some patients may require slit-lamp biomicroscopy & fluorescein staining

Advice patients not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis

Solution may harm corneal endothelial cells if introduced directly into anterior chamber

Points of recommendation

  • Tell all of your health care providers that you take gatifloxacin. This includes your doctors, nurses, pharmacists, and dentists.
  • Use care when driving or doing other tasks that call for clear eyesight.
  • Do not use longer than you have been told. A second infection may happen.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using gatifloxacin while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
  • To gain the most benefit, do not miss doses.
  • Use as you have been told, even if your signs get better.
  • Wash your hands before and after use.
  • Do not touch the container tip to the eye, lid, or other skin.
  • Tilt your head back and drop drug into the eye.
  • After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.
  • Avoid wearing contacts unless told to wear them by your doctor.
  • Use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses or extra doses.

Pregnancy level

Group c - Not adequate studies in pregnant women


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