Drug information of acrivastine+pseudoephedrine

Mechanism of effect

Acrivastine exhibits H1-antihistaminic receptor activity, which prevents histamine from binding to its receptor in target cells

Pseudoephedrine:  Indirect sympathomimetic agent, releases norepinephrine from adrenergic nerves

Pharmacodynamic

Not available

Pharmacokinetics

Half-Life

Acrivastine 1.9-3.5 hr; propionic acid metabolite 3.8 hrs

Pseudoephedrine 5-8 hr

Absorption

Rapid and complete

Vd

Acrivastine 0.46 L/kg

Pseudoephedrine 3 L/kg

Peak Plasma Time

Acrivastine 1.1 hr

Pseudoephedrine 1.97 hr

Peak Plasma Concentration

Acrivastine 227 ng/ml

Pseudoephedrine 422 ng/ml

Protein Bound

Acrivastine 50%

Pseudoephedrine minimal

Metabolism

Acrivastine 11% to propionic acid metabolite

Clearance

Acrivastine 2.9 mL/min/kg

Pseudoephedrine 5.9 mL/min/kg

Excretion

Acrivastine: feces (13%) urine (84%)

Pseudoephedrine: 55-75% renal (dependent on urine pH)

Drug indications

nasal stuffiness , Allergic Rhinitis

Dosage

Adult

Seasonal Allergic Rhinitis or Nasal Congestion

8 mg/60 mg (1 capsule) PO q4-6h

>14 days continuous treatment efficacy not adequately investigated

Pediatric

Seasonal Allergic Rhinitis or Nasal Congestion  

<12 years: Safety and efficacy not established

>12 years: 8 mg/60 mg (1 capsule) PO q4-6h

>14 days continuous treatment efficacy not adequately investigated  

Side effects

Insomnia , dry mouth , difficulty urinating , Restlessness

Interactions

potassium citrate , Amitriptyline , Isoflurane , Imipramine , Procarbazine , Trazodone , Tranylcypromine , rasagiline , protriptyline , Methoxyflurane , Doxapram , Ergoloid Mesylate , lofepramine , ergotamine , Linezolid , Phenelzine , Desflurane , Amoxapine , isocarboxazid , Maprotiline , Methylergonovin , Nortriptyline , Cabergoline , Clomipramine , Yohimbine , Trimipramine , Desipramine , Doxepin , Dihydroergotamine , Selegiline , Sevoflurane

Alerts

Due to potential for sedation, assess individual responses before engaging in any activity requiring mental alertness, such as driving a motor vehicle or operating machinery

Concurrent use with alcohol or other CNS depressants may cause additional reductions in alertness and impairment of CNS performance and should be avoided

Not adequately studied for relieving common cold symptoms

Points of recommendation

Use exactly as directed on the label, or as prescribed by your doctor. Allergy medicine is only for short-term use until your symptoms clear up.

Do not take acrivastine and pseudoephedrine for longer than 7 days in a row.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need surgery, tell the surgeon ahead of time if you have taken this medicine in the past few days.

Store at room temperature away from moisture, heat, and light.

Since acrivastine and pseudoephedrine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

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