Drug information of Mepenzolate

Mepenzolate


Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon.

Mechanism of effect

Mepenzolate is a post-ganglionic parasympathetic inhibitor. It specifically antagonizes muscarinic receptors. This leads to decreases in gastric acid and pepsin secretion and suppression of spontaneous contractions of the colon.

Pharmacodynamic

Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor.

Pharmacokinetics

Absorption: Limited

Excretion: Urine (3-33%) & feces

Drug indications

peptic ulcer

Dosage

Adult

Peptic Ulcer

25-50 mg PO q6hr (with meals & HS), titrate as needed

Elderly: Start at lower end of dose

Pediatric

Safety & efficacy not established

Alerts

Renal/hepatic impairment, BPH, CHF, CAD, HTN, COPD, hiatal hernia, reflux esophagitis, mitral stenosis, brain damage or spastic paralysis in children, salivary secretion disorder, Down syndrome, autonomic neuropathy, hyperthyroidism, tachyarrythmia, toxin-mediated diarrhea

Elderly

Risk of heat prostration in high environmental temperature

May affect alertness/ability to perform hazardous tasks

Points of recommendation

  • Tell all of your health care providers that you take mepenzolate. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how mepenzolate affects you.
  • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
  • Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
  • Talk with your doctor before you take antacids while you are taking mepenzolate.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using mepenzolate while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
  • Take with meals and at bedtime.
  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.


Ask a Pharmacist


User's questions
    No comments yet.