Drug information of Propiomazine


Propiomazine is used to produce sleepiness or drowsiness and to relieve anxiety before or during surgery or certain procedures. It is also used with analgesics (pain medicine) during labor to produce drowsiness and relieve anxiety.

Mechanism of effect

Propiomazine acts as an antagonist of dopamine 1, 2, and 4 receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect.


Although propiomazine is a phenothiazine, it is not used as an antipsychotic. It posesses antihistamine effects and is mostly used as a sedative in treating insomnia.


Protein binding: 81%

Metabolism: Unknown, but most likely hepatic as with other phenothiazines.

Time to peak serum concentration: 1 to 3 hours following intramuscular administration
Time to peak effect:
Intramuscular—Within 40 to 60 minutes.
Intravenous—Within 15 to 30 minutes.
Duration of action: About 3 to 6 hours
Elimination:     Unknown, but probably renal and biliary as with other phenothiazines.


Usual adult dose
Intramuscular or intravenous, 20 to 40 mg administered in conjunction with 50 mg of meperidine

Sedation during surgery with local, nerve block, or spinal anesthesia
Intramuscular or intravenous, 10 to 20 mg

Analgesia adjunct, during labor
Intramuscular or intravenous, 20 to 40 mg in the early stages of labor, then 20 to 40 mg of propiomazine administered in conjunction with 25 to 75 mg of meperidine when labor is definitely established. Doses may be repeated every three hours, if necessary.

Usual pediatric dose
Sedation prior to surgery; preanesthetic; or postoperative
Children up to 27 kg: Intramuscular or intravenous, 550 mcg (0.55 mg) to 1.1 mg per kg of body weight; or for

Children 2 to 4 years of age: Intramuscular or intravenous, 10 mg

Children 4 to 6 years of age: Intramuscular or intravenous, 15 mg

Children 6 to 12 years of age: Intramuscular or intravenous, 25 mg


Patients sensitive to other phenothiazines may be sensitive to this medication also.

Points of recommendation

using caution in driving or performing other tasks requiring alertness and coordination  until the effects of propiomazine have subsided or until the day after receiving propiomazine, whichever is longer

Avoiding use of alcohol or other CNS depressants within 24 hours after receiving propiomazine except as directed by physician or dentist

Related drugs

Pimozide , Haloperidol , Loxapine , Molindone

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