Drug information of Tripelennamine


Drug group: Antihistamine

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.

Mechanism of effect

Tripelennamine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.


Tripelennamine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.


Absorption: Well absorbed in the digestive tract.

Metabolism: Hepatic


Drug indications

allergic reaction


Not available


  • glaucoma or increased pressure in the eye;
  • a stomach ulcer;
  • an enlarged prostate, bladder problems, or difficulty urinating;
  • an overactive thyroid (hyperthyroidism);
  • high blood pressure or any type of heart problem; or
  • asthma.

Points of recommendation

Use caution when driving, operating machinery, or performing other hazardous activities. Tripelennamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking tripelennamine.

Do not crush, chew, or break the sustained-release forms of tripelennamine. Swallow them whole. They are specially formulated to release slowly in the body.

Take tripelennamine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Tripelennamine can be taken with food to lessen stomach upset.

To ensure that you get a correct dose, measure the elixir form of tripelennamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Store tripelennamine at room temperature away from moisture and heat.

Tripelennamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if tripelennamine is taken with any of these medications.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.


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