Drug information of Butenafine


Butenafine

Drug group:

Butenafine hydrochloride is a synthetic benzylamine antifungal agent.

Mechanism of effect

Although the mechanism of action has not been fully established, it has been suggested that butenafine, like allylamines, interferes with sterol biosynthesis (especially ergosterol) by inhibiting squalene monooxygenase, an enzyme responsible for converting squalene to 2,3-oxydo squalene. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Blockage of squalene monooxygenase also leads to a subsequent accumulation of squalene. When a high concentration of squalene is reached, it is thought to have an effect of directly kill fungal cells.

Pharmacodynamic

Butenafine is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is also active against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.

Pharmacokinetics

Peak Plasma Time: 8-15 hr

Metabolism: liver

Excretion: urine

Dosage

Adult

Tinea Pedis

Cream: Apply to affected areas BID for at least 1 week; not to exceed 4 weeks

Gel: Apply to affected area BID for 7 days

Solution: Apply to affected area BID for 7 days

Ringworm & Jock Itch (Tinea Corporis, Tinea Cruris)

Cream: Apply to affected area qDay/BID for at least 1 week; not to exceed 4 weeks

Gel: Apply to affected area once daily for 7 days

Solution: Apply to affected area qDay for 7 days in tinea corporis and tinea cruris; apply to affected areas BID for 7 days in tinea versicolor

Tinea (Pityriasis) Versicolor

Apply qDay for 2 weeks

Pediatric

Tinea Pedis

<12 years old: Safety & efficacy not established

>12 years old: As in adults

Ringworm & Jock Itch (Tinea Corporis, Tinea Cruris)

<12 years old: Safety & efficacy not established

>12 years old: As in adults

Drug contraindications

Hypersensitivity

Side effects

stinging

Interactions

Alerts

None

Points of recommendation

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Wash your hands before and after using this medicine.

Clean and dry the affected area. Apply the medicine as directed.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Call your doctor if your symptoms do not improve after 4 weeks of treatment, or if they get worse.

Do not cover the treated skin area unless your doctor tells you to.

Store at room temperature away from moisture and heat. Keep the medicine container tightly closed when not in use.

Apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not use extra medicine to make up the missed dose.

If butenafine topical gets in your eyes, nose, mouth, rectum, or vagina, rinse with water.

Avoid using other medications on the areas you treat with butenafine unless your doctor tells you to.

Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until your infection is healed.

Pregnancy level

Group c - Not adequate studies in pregnant women


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