Drug information of Ganirelix

Ganirelix


Ganirelix is an injectable competitive gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. Ganirelix is used in fertility treatment to prevent premature ovulation that could result in the harvesting of eggs that are too immature to be used in procedures such as in vitro fertilisation.

Mechanism of effect

Ganirelix acts by competitively blocking the GnRH receptors on the pituitary gonadotroph and subsequent transduction pathway. It induces a rapid, reversible suppression of gonadotropin secretion. The suppression of pituitary LH secretion by ganirelix is more pronounced than that of FSH.

 An initial release of endogenous gonadotropins has not been detected with ganirelix, which is consistent with an antagonist effect. Upon discontinuation of ganirelix, pituitary LH and FSH levels are fully recovered within 48 hours.

Pharmacokinetics

  • Half-Life: 12.8-16.2 hr (elimination)
  • Onset: Within 8 hr
  • Duration: <48 hr
  • Peak Plasma Time: ~1 hr
  • Bioavailability: 91%
  • Vd: 43.7 L (single dose); 76.5 L (multiple dosing)
  • Protein Bound: 82%
  • Metabolism: Liver
  • Total Body Clearance: 3-4 L/hr
  • Excretion: Feces (75%); urine (22%)

Dosage

Adult

Female Infertility

250 mcg SC qDay during mid-to-late follicular phase after initiating follicle-stimulating hormone on day 2 and 3 of the cycle, continue therapy until day of hCG administration

Pediatric

Not recommended

Drug contraindications

pregnancy , Hypersensitivity

Alerts

Exclude pregnancy before initiating therapy

Packaging may contain latex products, which may cause allergic reaction in susceptible patients

Use caution in women with sign and symptoms of active allergic conditions

Points of recommendation

Ganirelix is injected under the skin. You may be shown how to use injections at home. Do not self-inject ganirelix if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Follow your doctor's instructions and try not to miss any doses.

Each single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Store the prefilled syringe at room temperature, away from heat, moisture and light.

Call your doctor for instructions if you miss a dose.

Pregnancy level

X

Related drugs

Abarelix , Cetrorelix , Degarelix


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